Thanks Jerone,
using OMEGA of 0.01 instead of 0.07 (I did not try REALLY small OMEGAs) did
help.
Sven
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| Von: |
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|"Elassaiss - Schaap, J. (Jeroen)" <[email protected]>
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| An: |
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|Sven Mensing <[email protected]>
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| Datum: |
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|08.12.2011 10:43
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|RE: [NMusers] PRED EXIT in first ITERATION causes METHOD=COND to crash not
ITS |
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Hi Sven,
Have you tried to run a small number of ITS evals before starting with
FOCE? i.e. first an $EST line with ITS, than an $EST line with FOCE.
Alternatively, you could try to start with (1) improved initial estimates
or (2) with very small inits for $OMEGA which should minimize the chance of
hitting your exit boundaries during the first step.
Best regards,
Jeroen
J. Elassaiss-Schaap
Scientist PK/PD
MSD
PO Box 20, 5340 BH Oss, Netherlands
Phone: + 31 412 66 9320
Fax: + 31 412 66 2506
e-mail: [email protected]
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of Sven Mensing
Sent: Thursday, December 08, 2011 10:06
To: [email protected]
Subject: [NMusers] PRED EXIT in first ITERATION causes METHOD=COND to crash
not ITS
Hello,
can someone help me in how to run a rather complex PD model using
CONDitional estimation. The model produces errors during ETA search which
are very cumbersome to fetch, thus these errors are likely to persist.
Since COND does not have a problem with EXIT codes once the first (two?)
evaluation steps have been performed, I was wondering whether somebody
knows some kind of work-around for this.
E.g. ITS is not crashing due to initial ETA errors.
Thanks
Sven
Sven Mensing, PhD Abbott GmbH & Co. KG phone: +49 (0)621 589
Assistant Director, Knollstraße 50 1535
Principal Research 67061 Ludwigshafen fax: +49 (0)621 589
Statistician Germany 1925
Pharmacometrics [email protected]
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