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Extrapolation and bridging of efficacy in paediatric chronic and mixed pain.
PhD Position in Clinical Pharmacology & Therapeutics
University College London
Neuropathic pain in children has been considered rare although in the most
recent years the
prevalence seems increasing particularly in the contest of serious medical
conditions. This research project deals with pharmacokinetic (PK) and
pharmacokinetic-pharmacodynamic (PKPD) bridging and extrapolation concepts.
Gabapentin in paediatric pain (GAPP) is an FP7 consortium aimed at the
evaluation of chronic pain in children. The ultimate goal of this research is
to define the dosing recommendation for patients aged between 3 months to <18
years based on modelling and simulation techniques.
Data analysis will include the evaluation of the pharmacokinetics and
pharmacodynamics (clinical response) to treatment with morphine, tramadol and
gabapentin. Pharmacokinetic modelling will be performed to characterise drug
exposure using sparse PK sampling from adolescents and children. A population
approach will be used to describe response to treatment with gabapentin as well
as the reduction in morphine intake required to achieve analgesia.
The successful candidate will also be involved in the optimisation of clinical
trial protocols in paediatric pain research. In addition, given the nature of
the project, your responsibilities will include active interaction with
consortium partners and regulatory agencies. You will also be responsible for
effective project management, ensuring that milestones and deliverables of the
consortium are met.
Previous experience or training in clinical pharmacology and affinity with
bioanalytical techniques, statistical methods (PKPD modelling), including basic
knowledge of computer programming (R language) are essential. Basic Good
Clinical Practice (GCP) training and good communication skills in written and
spoken English are required for this position.
Details on how to apply can be found at:
http://www.ucl.ac.uk/pharmacy/courses-and-PhD/mphil-phd
For further information regarding the project and background, contact Prof O
Della Pasqua ([email protected]<mailto:[email protected]>).