Advanced Course on Applied Pharmacometrics

Register NOW…………… Advanced Course on Applied Pharmacometrics November 14-16, 2016: Château de Longcol, Lieu-dit Longcol, La Fouillade (France). Course outline * Determine the modelling strategy for characterizing the complex in-vivo absorption processes for extended release formulations (ER) and Long Acting Injectable (LAI) formulations using convolution-based approach * Evaluate In-Vitro/In-Vivo correlation methods, including convolution-deconvolution approach * Evaluate the relationship between drug exposure of extended release formulations and clinical response in presence of placebo effect and acute tolerance * Determine the relationship between drug delivery and clinical benefit * Determine the In-Vitro drug release to optimize the clinical benefit * Illustrate how the convolution-based approach can be used to optimize the performances of ER and LAI formulations * Determine the optimal study design methodology for study in a pediatric population for extended release formulations using the PopED software Course objectives * To develop a population PK model for describing multiphase absorption profiles * To evaluate alternative placebo response models * To develop indirect-response model to jointly evaluate the placebo and drug relate response * To evaluate the relative impact of the immediate and the delayed drug release on the therapeutic response * To use convolution-deconvolution methods for linking in-vitro to in-vivo outcomes * To determine the optimal drug formulation profiles for optimizing the performances of novel drug formulations * To evaluate optimal study design methodologies Course material * The R scripts (including Shiny based applications) used in the hands-on sessions and the NONMEM control streams used for implementing: * the convolution/deconvolution analysis, * the clinical trial simulator for describing the clinical response in presence of placebo and active drug response, * the estimation of the optimal in-vitro dissolution profiles * the convolution/deconvolution analysis, will be distributed to the participants. Venue : Château de Longcol, Lieu-dit Longcol, La Fouillade (France). http://www.chateaudelongcol.com/ http://www.chateaudelongcol.com/ Pre-view and play with our Shiny-based simulator by running on your PC or mobile device a PK/PD case study: http://www.pharmacometricasimulation.webs.com www.pharmacometricasimulation.webs.com Roberto Gomeni, PhD, HDR, Adjunct Professor at UNC Pharmacometrica Longcol, 12270 La Fouillade (France) E-mail: <mailto:[email protected]> [email protected] http://www.pharmacometrica.com/ www.pharmacometrica.com Next workshops on pharmacometrics: http://pharmacometricaworkshop.webs.com/

PharmacoMetrica is offering an advanced Course on Applied Pharmacometrics at the Chateau de Longcol (France) on November 14-16, 2016. Below a brief descriptions and a link to our website for more details and info on how to register. Register NOW Advanced Course on Applied Pharmacometrics November 14-16, 2016, Chateau de Longcol (France) This three-day course presents drug-disease-trial model strategies for optimizing drug development by applying pharmacometrics concepts. Case studies in Attention Deficit/Hyperactivity Disorder disease (ADHD) and in Schizophrenia will be presented and discussed. Course outline * Determine the modelling strategy for characterizing the complex in-vivo absorption processes for extended release formulations (ER) and Long Acting Injectable (LAI) formulations using convolution-based approach * Implement In-Vitro/In-Vivo correlation (IVIVC) using a convolution-based approach * Evaluate the relationship between drug exposure of extended release formulations and clinical response in presence of placebo effect and acute tolerance * Determine the relationship between drug delivery and clinical benefit using an integrated PK/PD models * Determine the In-Vitro drug release for optimizing the clinical benefit of a treatment * Illustrate how the convolution-based approach can be used to optimize the performances of ER and LAI formulations * Apply optimal study design methodologies for designing clinical studies in a pediatric population using optimal design tools and integrated PK/PD models The course will consist of both lectures and hands-on computer exercises. Please http://www.pharmacometricaworkshop.webs.com click here for additional details and registration information. http://www.pharmacometricaworkshop.webs.com/ www.pharmacometricaworkshop.webs.com Roberto Gomeni, PhD, HDR, Adjunct Professor with the Division of Pharmacotherapy and Experimental Therapeutics in the UNC Eshelman School of Pharmacy at The University of North Carolina at Chapel Hill PharmacoMetrica Longcol, 12270 La Fouillade (France) P Please Consider the Environment before printing this Email _____ Confidentiality Notice: This message is private and may contain confidential information. If you have received this message in error, please notify PharmacoMetrica, remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the contents of this message is not permitted and may be unlawful.

PharmacoMetrica is offering an advanced Course on Applied Pharmacometrics at the Chateau de Longcol (France) on November 14-16, 2016. Below a brief descriptions and a link to our website for more details and info on how to register. Final chance to register... Advanced Course on Applied Pharmacometrics November 14-16, 2016, Chateau de Longcol (France) This three-day course presents drug-disease-trial model strategies for optimizing drug development by applying pharmacometrics concepts. Case studies in Attention Deficit/Hyperactivity Disorder disease (ADHD) and in Schizophrenia will be presented and discussed. Course outline * Determine the modelling strategy for characterizing the complex in-vivo absorption processes for extended release formulations (ER) and Long Acting Injectable (LAI) formulations using convolution-based approach * Implement In-Vitro/In-Vivo correlation (IVIVC) using a convolution-based approach * Evaluate the relationship between drug exposure of extended release formulations and clinical response in presence of placebo effect and acute tolerance * Determine the relationship between drug delivery and clinical benefit using an integrated PK/PD models * Determine the In-Vitro drug release for optimizing the clinical benefit of a treatment * Illustrate how the convolution-based approach can be used to optimize the performances of ER and LAI formulations * Apply optimal study design methodologies for designing clinical studies in a pediatric population using optimal design tools and integrated PK/PD models The course will consist of both lectures and hands-on computer exercises. Please http://www.pharmacometricaworkshop.webs.com click here for additional details and registration information. http://www.pharmacometricaworkshop.webs.com/ www.pharmacometricaworkshop.webs.com Roberto Gomeni, PhD, HDR, Adjunct Professor with the Division of Pharmacotherapy and Experimental Therapeutics in the UNC Eshelman School of Pharmacy at The University of North Carolina at Chapel Hill Skype: roberto.gomeni http://www.linkedin.com/profile/view?id=68436618&trk=tab_pro Longcol, 12270 La Fouillade (France) E-mail: <mailto:[email protected]> [email protected] Phone: +33(0) 983 24 3188 Mobile: +33(0) 760 45 1976 http://www.pharmacometrica.com/ www.pharmacometrica.com Next workshops on pharmacometrics: http://pharmacometricaworkshop.webs.com/ http://pharmacometricaworkshop.webs.com/ Play with our Shiny-based simulator by running on your PC or mobile device a PK/PD case study: http://www.pharmacometricasimulation.webs.com/ www.pharmacometricasimulation.webs.com P Please Consider the Environment before printing this Email _____ Confidentiality Notice: This message is private and may contain confidential information. If you have received this message in error, please notify PharmacoMetrica, remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the contents of this message is not permitted and may be unlawful.