9th Fisher/Shafer NONMEM/PLT Tools Workshop

Dear Colleagues: I am happy to announce the 9th Fisher / Shafer NONMEM Workshop, which will be held in Bethesda, Maryland from Wednesday, May 6th, through Sunday, May 10th. You can see the course description and registration details at www.nonmemcourse.com. Our NONMEM Workshops are now in their 5th year. Dennis Fisher and I have spent the past two years developing PLT Tools, which has now completed its first year of testing. For the 9th Fisher/Shafer NONMEM course we have completed converted from the R scripts and Windows batch commands offered in our previous courses to the substantially more capable PLT Tools platform. You can download the completely functional non-licensed version of PLT Tools from www.pltsoft.com. Even if you don't install it, you should look at the user interface. Model validation is facilitated with automated procedures for visual predictive checks, log likelihood profiling, jack-knife analysis, and extensive bootstrap analysis for determination of standard errors. We are also including a robust library of control streams and a control stream editor. CFR 11 Part 22 compliance is built into the program, as is extensive run archiving and creation of audit trails. PLT Tools also includes a comprehensive set of graphical and statistical analyses facilitate model development and testing. A sample output can be downloaded from www.pltsoft.com. The licensed version of PLT Tools supports distributing NONMEM processing across networked computers. We hope to see you in Bethesda! Sincerely, Steven L. Shafer, MD Professor of Anesthesiology, Columbia University Adjunct Professor of Anesthesia, Stanford University Adjunct Professor of Biopharmaceutical Sciences, UCSF Editor-in-Chief, Anesthesia & Analgesia

Dear Colleagues: I am happy to announce the 9th Fisher / Shafer NONMEM Workshop, which will be held in Bethesda, Maryland from Wednesday, May 6th, through Sunday, May 10th. You can see the course description and registration details at www.nonmemcourse.com. Our NONMEM Workshops are now in their 5th year. Dennis Fisher and I have spent the past two years developing PLT Tools, which has now completed its first year of testing. For the 9th Fisher/Shafer NONMEM course we have completed converted from the R scripts and Windows batch commands offered in our previous courses to the substantially more capable PLT Tools platform. You can download the completely functional non-licensed version of PLT Tools from www.pltsoft.com. Even if you don't install it, you should look at the user interface. Model validation is facilitated with automated procedures for visual predictive checks, log likelihood profiling, jack-knife analysis, and extensive bootstrap analysis for determination of standard errors. We are also including a robust library of control streams and a control stream editor. CFR 11 Part 22 compliance is built into the program, as is extensive run archiving and creation of audit trails. PLT Tools also includes a comprehensive set of graphical and statistical analyses facilitate model development and testing. A sample output can be downloaded from www.pltsoft.com. The licensed version of PLT Tools supports distributing NONMEM processing across networked computers. One of the joys of teaching this course is the considerable evolution in course material every time the workshop is offered. Dennis and I continuous update the course materials, based both on feedback from course participants and our own exploration of novel pharmacometric problems. Now that we have converted our own work entirely to the PLT Tools platform, we think course participants will similarly benefit from a simple interface that provides outstanding diagnostic graphics, and automates advanced tasks including VPC, LL profiles, and bootstrap analysis. We hope to see you in Bethesda! Sincerely, Steven L. Shafer, MD Professor of Anesthesiology, Columbia University Adjunct Professor of Anesthesia, Stanford University Adjunct Professor of Biopharmaceutical Sciences, UCSF Editor-in-Chief, Anesthesia & Analgesia

Dear Colleagues: The 9th Fisher / Shafer NONMEM Workshop is about 2/3rds booked, which means that there are still a few seats available. We do not plan on offering another course in North America this year, so if you are interested in taking this advanced NONMEM course in the US this year, you need to sign up soon. The course will be held in Bethesda, Maryland from Wednesday, May 6th, through Sunday, May 10th. You can see the course description and registration details at www.nonmemcourse.com. Our NONMEM Workshops are now in their 5th year. Dennis Fisher and I have spent the past two years developing PLT Tools, which has now completed its first year of testing. For the 9th Fisher/Shafer NONMEM course we have completed converted from the R scripts and Windows batch commands offered in our previous courses to the substantially more capable PLT Tools platform. You can download the completely functional non-licensed version of PLT Tools from www.pltsoft.com. Even if you don't install it, you should look at the user interface. Model validation is facilitated with automated procedures for visual predictive checks, log likelihood profiling, jack-knife analysis, and extensive bootstrap analysis for determination of standard errors. We are also including a robust library of control streams and a control stream editor. CFR 11 Part 22 compliance is built into the program, as is extensive run archiving and creation of audit trails. PLT Tools also includes a comprehensive set of graphical and statistical analyses facilitate model development and testing. A sample output can be downloaded from www.pltsoft.com. The licensed version of PLT Tools supports distributing NONMEM processing across networked computers. One of the joys of teaching this course is the considerable evolution in course material every time the workshop is offered. Dennis and I continuous update the course materials, based both on feedback from course participants and our own exploration of novel pharmacometric problems. Now that we have converted our own work entirely to the PLT Tools platform, we think course participants will similarly benefit from a simple interface that provides outstanding diagnostic graphics, and automates advanced tasks including VPC, LL profiles, and bootstrap analysis. We hope to see you in Bethesda! Sincerely, Steven L. Shafer, MD Professor of Anesthesiology, Columbia University Adjunct Professor of Anesthesia, Stanford University Adjunct Professor of Biopharmaceutical Sciences, UCSF Editor-in-Chief, Anesthesia & Analgesia

Dear Colleagues: There are a few seats still available for the 9th Fisher / Shafer NONMEM Workshop, which is just 5 weeks away. We do not plan on offering another course in North America this year, so if you are interested in taking this advanced NONMEM course in the US this year, you need to sign up soon. The course will be held in Bethesda, Maryland from Wednesday, May 6th, through Sunday, May 10th. You can see the course description and registration details at www.nonmemcourse.com. Our NONMEM Workshops are now in their 5th year. Dennis Fisher and I have spent the past two years developing PLT Tools, which has now completed its first year of testing. For the 9th Fisher/Shafer NONMEM course we have completed converted from the R scripts and Windows batch commands offered in our previous courses to the substantially more capable PLT Tools platform. You can download the completely functional non-licensed version of PLT Tools from www.pltsoft.com. Even if you don't install it, you should look at the user interface. Model validation is facilitated with automated procedures for visual predictive checks, log likelihood profiling, jack-knife analysis, and extensive bootstrap analysis for determination of standard errors. We are also including a robust library of control streams and a control stream editor. CFR 11 Part 22 compliance is built into the program, as is extensive run archiving and creation of audit trails. PLT Tools also includes a comprehensive set of graphical and statistical analyses facilitate model development and testing. A sample output can be downloaded from www.pltsoft.com. The licensed version of PLT Tools supports distributing NONMEM processing across networked computers. One of the joys of teaching this course is the considerable evolution in course material every time the workshop is offered. Dennis and I continuous update the course materials, based both on feedback from course participants and our own exploration of novel pharmacometric problems. Now that we have converted our own work entirely to the PLT Tools platform, we think course participants will similarly benefit from a simple interface that provides outstanding diagnostic graphics, and automates advanced tasks including VPC, LL profiles, and bootstrap analysis. We hope to see you in Bethesda! Sincerely, Steven L. Shafer, MD Professor of Anesthesiology, Columbia University Adjunct Professor of Anesthesia, Stanford University Adjunct Professor of Biopharmaceutical Sciences, UCSF Editor-in-Chief, Anesthesia & Analgesia