From tmj@cptvs4.cvm.ncsu.edu Sun May 4 10:14:15 1997
Subject: 3 compartment model TRANS and ADVAN
We are conducting an study with NONMEM at NC State University in which we are trying to fit datapoints obtained both from blood and a peripheral compartment using a three compartment structural model. All the rate constants are first order and elimination is from the central compartment. We have a data rich situation for the blood compartment and a sparse data situation for the observations from the peripheral compartment.
What advan and trans subroutines should be used?.
Is there a model already built-up in NONMEM to handle this, and if not, what kind of user-defined code should we input?.
Thanks.