12th Fisher/Shafer NONMEM Workshop with PLT Tools

Dear Colleagues: Dennis Fisher and I are pleased to announce the 12th Fisher/Shafer NONMEM Workshop with PLT Tools, to be held in Bethesda, Maryland from Wednesday, November 3rd, 2010 through Saturday, November 6th, 2010. You can find the course description and registration details at www.nonmemcourse.com. This is an intermediate to advanced course on the use of the NONMEM System, closely integrated with the PLT Tools graphical user interface for the NONMEM System. Although the focus of the workshop is NONMEM, the more advanced diagnostics (e.g., visual predictive check, log-likelihood profiling, bootstrap analysis, jackknife validation) are presented in the context of PLT Tools because it automates the generation of these diagnostics. We introduced automatic covariate searching at the April workshop in San Francisco, where it was very well received. We also introduced batch processing of control files and automatic report generation (in RTF format), frequent requests of NONMEM users in a production environment, again to very positive user feedback. Automatic covariate searching, batch processing of NONMEM files, and automatic report generation will be a standard part of all future courses. The workshop will be based on NONMEM VI, the standard version of NONMEM for most users. PLT Tools fully supports NONMEM 7. PLT Tools also supports NMQUAL, for users who have incorporated NMQUAL into their work environment. Our NONMEM Workshops are now in their 6th year. Dennis and I have spent the past four years developing PLT Tools. We introduced PLT Tools in Bethesda, Maryland in 2009, and have used the biannual workshops to introduce new features of PLT Tools. The feedback from the three courses since we introduced PLT Tools (9th, 10th, and 11th) is that workshop participants appreciated having access to the powerful features of the PLT Tools program. You can download the fully functional unlicensed version of PLT Tools from www.pltsoft.com. Participants are encouraged to consider two introductory courses: . Introduction to R: The day before the workshop (Tuesday, November 2nd), we teach two half-day courses: "Data Manipulation" (Tuesday morning) and "Statistics and Graphics (Tuesday afternoon). . Introduction to NONMEM: Participants who would like to brush up on NONMEM before starting the workshop on Wednesday are encouraged to attend this half-day session (Tuesday afternoon). Participants interested in additional training in PLT Tools can sign up for a half-day course devoted to PLT Tools we give on the afternoon of the last day (Saturday, November 6th). The course covers PLT Tools in far greater detail, focusing on a series of examples in which PLT Tools handles types of data analysis that are unwieldy if one attempts to work directly with NONMEM. Dennis and I hope to see you in November in Bethesda! Sincerely, Steven L. Shafer, MD Professor of Anesthesiology, Columbia University Adjunct Professor of Anesthesia, Stanford University Adjunct Professor of Biopharmaceutical Sciences, UCSF Editor-in-Chief, Anesthesia & Analgesia

Dear Colleagues: Dennis Fisher and I are pleased to announce the 12th Fisher/Shafer NONMEM Workshop with PLT Tools, to be held in Bethesda, Maryland from Wednesday, November 3rd, 2010 through Saturday, November 6th, 2010. You can find the course description and registration details at www.nonmemcourse.com. This is an intermediate to advanced course on the use of the NONMEM System, closely integrated with the PLT Tools graphical user interface for the NONMEM System. Although the focus of the workshop is NONMEM, the more advanced diagnostics (e.g., visual predictive check, log-likelihood profiling, bootstrap analysis, jackknife validation) are presented in the context of PLT Tools because it automates the generation of these diagnostics. We introduced automated covariate searching at the April workshop in San Francisco, where it was very well received. We also introduced batch processing of control files and automated report generation, frequent requests of NONMEM users in a production environment, again to very positive user feedback. Automatic covariate searching, batch processing of NONMEM files, and automatic report generation will be a standard part of all future courses. The workshop will be based on NONMEM VI, the standard version of NONMEM for most users. PLT Tools fully supports NONMEM 7. PLT Tools also supports NMQUAL, for users who have incorporated NMQUAL into their work environment. Our NONMEM Workshops are now in their 6th year. Dennis and I have spent the past four years developing PLT Tools. We introduced PLT Tools in Bethesda, Maryland in 2009, and have used the biannual workshops to introduce new features of PLT Tools. The feedback from the three courses since we introduced PLT Tools (9th, 10th, and 11th) is that workshop participants appreciated having access to the powerful features of the PLT Tools program. You can download the fully functional unlicensed version of PLT Tools from www.pltsoft.com. Participants are encouraged to consider two introductory courses: . Introduction to R: The day before the workshop (Tuesday, November 2nd), we teach two half-day courses: "Data Manipulation" (Tuesday morning) and "Statistics and Graphics (Tuesday afternoon). . Introduction to NONMEM: Participants who would like to brush up on NONMEM before starting the workshop on Wednesday are encouraged to attend this half-day session (Tuesday afternoon). Participants interested in additional training in PLT Tools can sign up for a half-day course devoted to PLT Tools we give on the afternoon of the last day (Saturday, November 6th). The course covers PLT Tools in far greater detail, focusing on a series of examples in which PLT Tools handles types of data analysis that are unwieldy if one attempts to work directly with NONMEM. Dennis and I hope to see you in November in Bethesda! Sincerely, Steven L. Shafer, MD Professor of Anesthesiology, Columbia University Adjunct Professor of Anesthesia, Stanford University Adjunct Professor of Biopharmaceutical Sciences, UCSF Editor-in-Chief, Anesthesia & Analgesia

Dear Colleagues: The 12th Fisher/Shafer NONMEM Workshop with PLT Tools will be held in Bethesda, Maryland from Wednesday, November 3rd, 2010 through Saturday, November 6th, 2010. You can find the course description and registration details at http://www.nonmemcourse.com www.nonmemcourse.com. This is an intermediate to advanced course on the use of the NONMEM System, closely integrated with the PLT Tools graphical user interface for the NONMEM System. Although the focus of the workshop is NONMEM, the more advanced diagnostics (e.g., visual predictive check, log-likelihood profiling, bootstrap analysis, jackknife validation) are presented in the context of PLT Tools because it automates the generation of these diagnostics. We introduced automated covariate searching at the April workshop in San Francisco, where it was very well received. We also introduced batch processing of control files and automated report generation, frequent requests of NONMEM users in a production environment, again to very positive user feedback. Automatic covariate searching, batch processing of NONMEM files, and automatic report generation will be a standard part of all future courses. The workshop will be based on NONMEM VI, the standard version of NONMEM for most users. PLT Tools fully supports NONMEM 7. PLT Tools also supports NMQUAL, for users who have incorporated NMQUAL into their work environment. Our NONMEM Workshops are now in their 6th year. Dennis and I have spent the past four years developing PLT Tools. We introduced PLT Tools in Bethesda, Maryland in 2009, and have used the biannual workshops to introduce new features of PLT Tools. The feedback from the three courses since we introduced PLT Tools (9th, 10th, and 11th) is that workshop participants appreciated having access to the powerful features of the PLT Tools program. You can download the fully functional unlicensed version of PLT Tools from http://www.pltsoft.com www.pltsoft.com. Participants are encouraged to consider two introductory courses: . Introduction to R: The day before the workshop (Tuesday, November 2nd), we teach two half-day courses: "Data Manipulation" (Tuesday morning) and "Statistics and Graphics (Tuesday afternoon). . Introduction to NONMEM: Participants who would like to brush up on NONMEM before starting the workshop on Wednesday are encouraged to attend this half-day session (Tuesday afternoon). Participants interested in additional training in PLT Tools can sign up for a half-day course devoted to PLT Tools we give on the afternoon of the last day (Saturday, November 6th). The course covers PLT Tools in far greater detail, focusing on a series of examples in which PLT Tools handles types of data analysis that are unwieldy if one attempts to work directly with NONMEM. Dennis and I hope to see you in November in Bethesda! Sincerely, Steven L. Shafer, MD Professor of Anesthesiology, Columbia University Adjunct Professor of Anesthesia, Stanford University Adjunct Professor of Biopharmaceutical Sciences, UCSF Editor-in-Chief, Anesthesia & Analgesia

Dear Colleagues: I apologize for the unsolicited spam! Nevertheless, this is the best venue for sharing with our colleagues in the PK/PD community that Dennis Fisher and I are still accepting enrollments for the 12th Fisher/Shafer NONMEM Workshop with PLT Tools, which will be held in Bethesda, Maryland from Wednesday, November 3rd, 2010 through Saturday, November 6th, 2010. You can find the course description and registration details at http://www.nonmemcourse.com www.nonmemcourse.com. This is an intermediate to advanced course on the use of the NONMEM System, closely integrated with the PLT Tools graphical user interface for the NONMEM System. Although the focus of the workshop is NONMEM, the more advanced diagnostics (e.g., visual predictive check, log-likelihood profiling, bootstrap analysis, jackknife validation) are presented in the context of PLT Tools because it automates the generation of these diagnostics. We introduced automated covariate searching at the April workshop in San Francisco, where it was very well received. We also introduced batch processing of control files and automated report generation, frequent requests of NONMEM users in a production environment, again to very positive user feedback. Automatic covariate searching, batch processing of NONMEM files, and automatic report generation will be a standard part of all future courses. The workshop will be based on NONMEM VI, the standard version of NONMEM for most users. PLT Tools fully supports NONMEM 7. PLT Tools also supports NMQUAL, for users who have incorporated NMQUAL into their work environment. Our NONMEM Workshops are now in their 6th year. Dennis and I have spent the past four years developing PLT Tools. We introduced PLT Tools in Bethesda, Maryland in 2009, and have used the biannual workshops to introduce new features of PLT Tools. The feedback from the three courses since we introduced PLT Tools (9th, 10th, and 11th) is that workshop participants appreciated having access to the powerful features of the PLT Tools program. You can download the fully functional unlicensed version of PLT Tools from http://www.pltsoft.com www.pltsoft.com. Participants are encouraged to consider two introductory courses: . Introduction to R: The day before the workshop (Tuesday, November 2nd), we teach two half-day courses: "Data Manipulation" (Tuesday morning) and "Statistics and Graphics (Tuesday afternoon). . Introduction to NONMEM: Participants who would like to brush up on NONMEM before starting the workshop on Wednesday are encouraged to attend this half-day session (Tuesday afternoon). Participants interested in additional training in PLT Tools can sign up for a half-day course devoted to PLT Tools we give on the afternoon of the last day (Saturday, November 6th). The course covers PLT Tools in far greater detail, focusing on a series of examples in which PLT Tools handles types of data analysis that are unwieldy if one attempts to work directly with NONMEM. Dennis and I hope to see you in November in Bethesda! Sincerely, Steven L. Shafer, MD Professor of Anesthesiology, Columbia University Adjunct Professor of Anesthesia, Stanford University Adjunct Professor of Biopharmaceutical Sciences, UCSF Editor-in-Chief, Anesthesia & Analgesia

Dear Colleagues: More spam about our NONMEM course - sorry! Dennis Fisher and I are still accepting enrollments for the 12th Fisher/Shafer NONMEM Workshop with PLT Tools, which will be held in Bethesda, Maryland from Wednesday, November 3rd, 2010 through Saturday, November 6th, 2010. You can find the course description and registration details at http://www.nonmemcourse.com www.nonmemcourse.com. This is an intermediate to advanced course on the use of the NONMEM System, closely integrated with the PLT Tools graphical user interface for the NONMEM System. Although the focus of the workshop is NONMEM, the more advanced diagnostics (e.g., visual predictive check, log-likelihood profiling, bootstrap analysis, jackknife validation) are presented in the context of PLT Tools because it automates the generation of these diagnostics. We introduced automated covariate searching at the April workshop in San Francisco, where it was very well received. We also introduced batch processing of control files and automated report generation, frequent requests of NONMEM users in a production environment, again to very positive user feedback. Automatic covariate searching, batch processing of NONMEM files, and automatic report generation will be a standard part of all future courses. The workshop will be based on NONMEM VI, the standard version of NONMEM for most users. PLT Tools fully supports NONMEM 7. PLT Tools also supports NMQUAL, for users who have incorporated NMQUAL into their work environment. Our NONMEM Workshops are now in their 6th year. Dennis and I have spent the past four years developing PLT Tools. We introduced PLT Tools in Bethesda, Maryland in 2009, and have used the biannual workshops to introduce new features of PLT Tools. The feedback from the three courses since we introduced PLT Tools (9th, 10th, and 11th) is that workshop participants appreciated having access to the powerful features of the PLT Tools program. You can download the fully functional unlicensed version of PLT Tools from http://www.pltsoft.com www.pltsoft.com. Participants are encouraged to consider two introductory courses: . Introduction to R: The day before the workshop (Tuesday, November 2nd), we teach two half-day courses: "Data Manipulation" (Tuesday morning) and "Statistics and Graphics (Tuesday afternoon). . Introduction to NONMEM: Participants who would like to brush up on NONMEM before starting the workshop on Wednesday are encouraged to attend this half-day session (Tuesday afternoon). Participants interested in additional training in PLT Tools can sign up for a half-day course devoted to PLT Tools we give on the afternoon of the last day (Saturday, November 6th). The course covers PLT Tools in far greater detail, focusing on a series of examples in which PLT Tools handles types of data analysis that are unwieldy if one attempts to work directly with NONMEM. Dennis and I hope to see you in November in Bethesda! Sincerely, Steven L. Shafer, MD Professor of Anesthesiology, Columbia University Adjunct Professor of Anesthesia, Stanford University Adjunct Professor of Biopharmaceutical Sciences, UCSF Editor-in-Chief, Anesthesia & Analgesia