Dear NM users,
I have often noticed the following error message on NM chat but I have never
really found a concrete solution to resolve it. I might have missed it.
Can anyone advise how to fix this error?
0PRED EXIT CODE = 1
0INDIVIDUAL NO. 4 ID= 4.00000000000000E+00 (WITHIN-INDIVIDUAL) DATA
REC NO. 2
THETA=
1.00E-03 5.00E-01 1.00E+01 1.00E+01 1.00E-01 1.00E+01 1.00E+00
OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0
F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN).
Elapsed estimation time in seconds: 0.00
Thank you in advance for your help
Marie
Marie RAJERISON
PharmD PhD
Pharmacometrician
e-mail:
[email protected]<mailto:[email protected]>
128 rue de la Boetie
75008 Paris
France
[cid:[email protected]]
0PRED EXIT CODE = 1
Hi Marie,
Can you please share your $ERROR block?
Thanks
Quoted reply history
________________________________
From: [email protected] <[email protected]> on behalf of
Marie Rajerison <[email protected]>
Sent: Wednesday, September 18, 2024 5:22 AM
To: [email protected] <[email protected]>
Subject: [External] [NMusers] 0PRED EXIT CODE = 1
Dear NM users, I have often noticed the following error message on NM chat but
I have never really found a concrete solution to resolve it. I might have
missed it. Can anyone advise how to fix this error? 0PRED EXIT CODE = 1
0INDIVIDUAL NO.
Dear NM users,
I have often noticed the following error message on NM chat but I have never
really found a concrete solution to resolve it. I might have missed it.
Can anyone advise how to fix this error?
0PRED EXIT CODE = 1
0INDIVIDUAL NO. 4 ID= 4.00000000000000E+00 (WITHIN-INDIVIDUAL) DATA
REC NO. 2
THETA=
1.00E-03 5.00E-01 1.00E+01 1.00E+01 1.00E-01 1.00E+01 1.00E+00
OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0
F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN).
Elapsed estimation time in seconds: 0.00
Thank you in advance for your help
Marie
Marie RAJERISON
PharmD PhD
Pharmacometrician
e-mail:
[email protected]<mailto:[email protected]>
128 rue de la Boetie
75008 Paris
France
[cid:[email protected]]
********************************************************************
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dissemination, distribution or copying of this email, or any attachment hereto,
is strictly prohibited. If you receive this email in error please immediately
notify me by return electronic mail and permanently delete this email and any
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business dealings with any third party.
********************************************************************
This is a generic error message, nothing informative except indicates that there are some numerical problems.
You can try to change ADVAN (6 to 13, if this is differential equations model) or TOL on $SUBR record, SIGL and NSIG on $EST, change initial conditions to the values of the previous model (assuming that there was some model) or to a realistic range. Sometimes MCETA=1000 on $EST recods helps with this message. Often this is related to the outliers, so it helps to clean the data. One can try to increase initial values of $SIGMAs or add random effect on the residual error.
If this is a complex model, you may try to start with something simple, like linear, and use the output as initial parameters, and also look for outliers (very large CWRES).
Thank you
Leonid
Quoted reply history
On 9/18/2024 8:09 AM, Sébastien Bihorel wrote:
> Hi Marie,
>
> Can you please share your $ERROR block?
>
> Thanks
> ------------------------------------------------------------------------
>
> *From:* [email protected] < [email protected] > on behalf of Marie Rajerison < [email protected] >
>
> *Sent:* Wednesday, September 18, 2024 5:22 AM
> *To:* [email protected] <[email protected]>
> *Subject:* [External] [NMusers] 0PRED EXIT CODE = 1
>
> Dear NM users, I have often noticed the following error message on NM chat but I have never really found a concrete solution to resolve it. I might have missed it. Can anyone advise how to fix this error? 0PRED EXIT CODE = 1 0INDIVIDUAL NO.
>
> Dear NM users,
>
> I have often noticed the following error message on NM chat but I have never really found a concrete solution to resolve it. I might have missed it.
>
> Can anyone advise how to fix this error?
>
> 0PRED EXIT CODE = 1
>
> 0INDIVIDUAL NO. 4 ID= 4.00000000000000E+00 (WITHIN-INDIVIDUAL) DATA REC NO. 2
>
> THETA=
>
> 1.00E-03 5.00E-01 1.00E+01 1.00E+01 1.00E-01 1.00E+01 1.00E+00
>
> OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0
>
> F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN).
>
> Elapsed estimation time in seconds: 0.00
>
> Thank you in advance for your help
>
> Marie
>
> *Marie RAJERISON*
>
> *PharmD PhD*
>
> *Pharmacometrician*
>
> *e-mail: [email protected] < mailto: [email protected] >*
>
> 128 rue de la Boetie
>
> 75008 Paris
>
> France
>
> ********************************************************************
>
> This e-mail and any attachment hereto, is intended only for use by the addressee(s) named above and may contain legally privileged and/or confidential information. If you are not the intended recipient of this e-mail, any dissemination, distribution or copying of this email, or any attachment hereto, is strictly prohibited. If you receive this email in error please immediately notify me by return electronic mail and permanently delete this email and any attachment hereto, any copy of this e-mail and of any such attachment, and any printout thereof. Finally, please note that only authorized representatives of Regeneron Pharmaceuticals, Inc. have the power and authority to enter into business dealings with any third party.
>
> ********************************************************************
Dear Sebastien,
Here is my $ERROR block :
$ERROR
IPRED=F
RUV_P=F*THETA(7)
;RUV_A=THETA(8)
SD=SQRT(RUV_P*RUV_P)
Y=F+ERR(1)*SD
IRES=DV-IPRED
IWRES=IRES/SD
Thank you for your help
Marie
Quoted reply history
De : Sébastien Bihorel <[email protected]>
Envoyé : mercredi 18 septembre 2024 14:10
À : Marie Rajerison <[email protected]>; [email protected]
Objet : Re: 0PRED EXIT CODE = 1
Hi Marie,
Can you please share your $ERROR block?
Thanks
________________________________
From: [email protected]<mailto:[email protected]>
<[email protected]<mailto:[email protected]>> on behalf
of Marie Rajerison
<[email protected]<mailto:[email protected]>>
Sent: Wednesday, September 18, 2024 5:22 AM
To: [email protected]<mailto:[email protected]>
<[email protected]<mailto:[email protected]>>
Subject: [External] [NMusers] 0PRED EXIT CODE = 1
Dear NM users, I have often noticed the following error message on NM chat but
I have never really found a concrete solution to resolve it. I might have
missed it. Can anyone advise how to fix this error? 0PRED EXIT CODE = 1
0INDIVIDUAL NO.
Dear NM users,
I have often noticed the following error message on NM chat but I have never
really found a concrete solution to resolve it. I might have missed it.
Can anyone advise how to fix this error?
0PRED EXIT CODE = 1
0INDIVIDUAL NO. 4 ID= 4.00000000000000E+00 (WITHIN-INDIVIDUAL) DATA
REC NO. 2
THETA=
1.00E-03 5.00E-01 1.00E+01 1.00E+01 1.00E-01 1.00E+01 1.00E+00
OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0
F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN).
Elapsed estimation time in seconds: 0.00
Thank you in advance for your help
Marie
Marie RAJERISON
PharmD PhD
Pharmacometrician
e-mail:
[email protected]<mailto:[email protected]>
128 rue de la Boetie
75008 Paris
France
[cid:[email protected]]
********************************************************************
This e-mail and any attachment hereto, is intended only for use by the
addressee(s) named above and may contain legally privileged and/or confidential
information. If you are not the intended recipient of this e-mail, any
dissemination, distribution or copying of this email, or any attachment hereto,
is strictly prohibited. If you receive this email in error please immediately
notify me by return electronic mail and permanently delete this email and any
attachment hereto, any copy of this e-mail and of any such attachment, and any
printout thereof. Finally, please note that only authorized representatives of
Regeneron Pharmaceuticals, Inc. have the power and authority to enter into
business dealings with any third party.
********************************************************************