NONMEM error

Colleagues Yesterday, I asked the group for suggestions to deal with a NONMEM error that appeared to result from a lengthy interval between doses causing NONMEM to abort. I received many suggestions. The one that I implemented successfully was to add records with EVID=3 2.0 days after the record at the beginning of the interval (suggested by Bill Denney and Jeroen Elassaiss-Schapp via email and Steve Shafer via phone). For example, if there were dose records at 0, 30, and 60-90 days, I added records at 2.0 and 32.0 days. Problem solved. Thanks for the prompt response from the community. Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone / Fax: 1-866-PLessThan (1-866-753-7784) www.PLessThan.com