Re: Emax model
Dear Marie,
There are basically two options:
1. Develop a sequential PK/PD model. First you develop a PK model and you
read out the individual predictions for concentrations (IPREDs). Then, using
the $PRED subroutine in NONMEM in a new run you can fit an EMAX equation to
your PD as dependent value and the IPREDs as independent value.
2. Alternatively, you can develop a simultaneous PK/PD model. You then
observe the PK and PD in the same compartment using two separate lines in your
dataset, with a column with a flag whether an observation is a PK or PD
observation. In the $ERROR block of your model you use two different equations
for your residual error where you let your PD error function depend on the
individual prediction for concentration in the central compartment. A hybrid
method would be first to develop a PK model, fix the THETA/OMEGA/SIGMA for PK
and add the PD model to this PK model, using the error block to describe the
relationship.
Sincerely,
Rob
Van: [email protected] <[email protected]> namens Marie
Rajerison <[email protected]>
Datum: woensdag, 9 oktober 2024 om 14:31
Aan: [email protected] <[email protected]>
Onderwerp: [NMusers] Emax model
Dear NM users,
Hope my message finds you well,
Can anyone share NM control streams for a direct Emax PK/PD model?
Thank you in advance for your help
Marie
Marie RAJERISON
PharmD PhD
Pharmacometrician
e-mail:
[email protected]<mailto:[email protected]>
128 rue de la Boetie
75008 Paris
France
[cid:[email protected]]
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