Re: %RSE for IIV when expressed as %CV instead of variance
Dear Anita,
You can find all details in {shameless plug} our PSP tutorial on log-normal variability: https://ascpt.onlinelibrary.wiley.com/doi/full/10.1002/psp4.12507
or go straight to the cheatsheet https://ascpt.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fpsp4.12507&file=psp412507-sup-0002-TableS1.pdf from there you get the CV as
sqrt(exp(OMEGA)-1) .
The SE is usually approximated as SE/OMEGA/2
The above is assuming the usual expression of PARM = THETA(x)*EXP(ETA(y)) and OMEGA for the variance estimate.
Hope this helps,
Jeroen
http://pd-value.com
[email protected]
@PD_value
+31 6 23118438
-- More value out of your data!
Quoted reply history
On 11-05-2024 16:08, Anita Moein wrote:
> Dear All:
>
> I have a question regarding reporting ETAs as %CV instead of variance.
>
> In NONMEM the IIV estimate is reported as variance with associated RSE%.
>
> How can I convert the IIV Estimate and RSE% to report it as CV%?
>
> Thank you!
>
> Best,
> Anita
>
> *Anita Moein*
> Senior Scientist
> Modeling and Simulation | Clinical Pharmacology | Genentech
> Phone: (650) 866 7701 | Cell: (415) 254 7972