Combined PK model
Hi All,
I have 4 studies with (1compound/study1-IV, 2compounds/study2-SC,
3compounds/study 3-IV , 3 compounds /study4-IV & SC). Maximum of 3
compounds/study. Thetas are shared and some of them have compound specific
and etas are shared. $MODEL COMP=9. Partial code is given below. Is this
right approach?. Any comments would be appreciated.
Thanks.
$PK
;Typical
LCL = THETA(1)
;stdy1
IF (STDY.EQ.1) THEN ; comp1
CLA = EXP(LCL + ETA(1))
‘’’’’’’’’’’’’’’’’’
ENDIF
;stdy-2
LCL_C1 = LCL + THETA(2)
LCL_C2 = LCL + THETA(3)
IF (STDY.EQ.2) THEN;
CLA = EXP(LCL_C1 + ETA(1)) ; comp1
CLB = EXP(LCL_C2 + ETA(1)); , comp2
‘’’’’’’’’’’’’’’’’’’’
ENDIF
;stdy3
LCL_C3 = LCL + THETA(4)
LCL_C4 = LCL + THETA(5)
LCL_C5 = LCL + THETA(6)
IF (STDY.EQ.3) THEN;
CLA = EXP(LCL_C3 + ETA(1)) ; comp3
CLB = EXP(LCL_C4 + ETA(1)); , comp4
CLC = EXP(LCL_C5 + ETA(1)); , comp5
‘’’’’’’’’’’’’’’’’’’’
ENDIF
$DES
;A
DADT(1) = - KaA * A(1)
DADT(2) = KaA * A(1) - Kc0A * A(2) - KcpA * A(2) + KpcA * A(3)
DADT(3) = KcpA * A(2) - KpcA * A(3)
;B
DADT(4) = - KaB * A(4)
DADT(5) = KaB * A(4) - Kc0B * A(5) - KcpB * A(5) + KpcB * A(6)
DADT(6) = KcpB * A(5) - KpcB * A(6)
;C
DADT(7) = - KaC * A(7)
DADT(8) = KaC * A(7) - Kc0C * A(8) - KcpC * A(8) + KpcC * A(9)
DADT(9) = KcpC * A(8) - KpcC * A(9)