Re: NONMEM Error on SAEM but not FOCEI
Dear Omar,
What you describe is not that strange. It can happen because SAEM does random sampling whereas FOCE-I uses a directed search. Therefore extreme values can occur with SAEM. Please refer to the section I60 of user guide for v7+ "Stable Routines for Estimation Methods and Automated Protection Against Floating Point Exceptions" for more detail, but you could start with including
$ABBR PROTECT
which probably is adequate in your case.
Hope this helps,
Jeroen
http://pd-value.com
[email protected]
@PD_value
+31 6 23118438
-- More value out of your data!
Quoted reply history
On 26-01-2024 16:01, Elashkar, Omar I. wrote:
> Hello NMusers,
>
> I have created a model that fit ok with FOCE+I. When I try to fit with SAEM, I get the following error:
>
> """
> ERROR IN TRANS4 ROUTINE: Q IS ZERO
> Elapsed estimation time in seconds: 0.00
> INDIVIDUAL OBJECTIVE FUNCTION VALUES ARE ALL ZERO. PROBLEM ENDED
> """
>
> The data is very small, but the model seems acceptable from bootstrap on FOCE+I. Any ideas are appreciated!
>
> Thank you,
> Omar
>
> *Omar Elashkar, *B.Pharm, MSc
>
> Graduate Assistant
>
> University of Florida | College of Pharmacy