Simulate with ETAs from .phi and residual variability

From: Philip Harder Delff Date: October 08, 2023 technical Source: mail-archive.com
Dear all, I want to simulate subjects with ETAs estimated. I use the .phi file using a $ETAS statement like: $ETAS FILE=file.phi FORMAT=s1pE15.8 TBLN=1 As far as I understand that has to be accompanied by a $ESTIMATION step that specifies FNLETA=2 like this: $ESTIMATION MAXEVAL=0 NOABORT METHOD=1 INTERACTION FNLETA=2 $SIM ONLYSIM does not work with $ESTIMATION so instead I just do: $SIMULATION (220412) This however means that in the following from $ERROR we don't get the ERR(1) and ERR(2) simulated and so Y=IPRED. Y=F+F*ERR(1)+ERR(2) I need to be able to edit the phi file to only simulate a subset of the patients so I can't use msf based solutions. Can I somehow use $ETAS without $ESTIMATION? Or how else can I get it to simulate the residual variability? Thank you, Philip
Oct 08, 2023 Philip Harder Delff Simulate with ETAs from .phi and residual variability
Oct 09, 2023 Leonid Gibiansky Re: Simulate with ETAs from .phi and residual variability
Oct 09, 2023 Andreas Lindauer RE: Simulate with ETAs from .phi and residual variability
Oct 09, 2023 Philip Harder Delff Re: Simulate with ETAs from .phi and residual variability