Problem with estimating sigma when using M3 method
Hello
I'm fairly new to nonmem, I'm currently trying to model a phase 1 study with
BLQ values, while the run was successful with no error message, my residual
error has a %rse >70 and a confidence interval that includes zero.
Here's my code:
$ERROR
LOQ=0.1
IPRED = F
SD = THETA(8)*IPRED
DEL = 0
IF(SD.EQ.0) DEL = 1
IRES = DV - IPRED
IWRES = IRES / (SD + DEL)
DUM = (LOQ -IPRED) / (SD + DEL)
CUMD = PHI(DUM) + DEL
IF(BLQ.EQ.0) THEN
F_FLAG=0
Y= IPRED +SD*ERR(1)
ELSE
F_FLAG=1
Y=CUMD
MDVRES = 1
ENDIF
$EST METHOD=1 INTERACTION LAPLACIAN PRINT=5 MAX=9999 SIG=3 SLOW NUMERICAL
MSFO=*.msf
$SIGMA
0.38 ;[P] sigma(1,1) (estimated in a previous model)
Furthermore, when trying to fit this model to my phase 2 dataset, covariance
step fails when I implement it.
Any suggestions are welcome
Thank you