llp function in PsN

Dear NMusers, to get an idea of the uncertainty of my estimated parameters, I recently tried using the llp (log-likelihood profiling) function of PsN (in Pirana). I also created plots using the incorporated R-code. I now wanted to ask if someone knows how I could “force” llp to try further plausible estimate values than just 10 in order to obtain a smoother plot. I have attached the llp plot of my V2 estimate; the curve appears to be very rough and imprecise. Unfortunately, for this specific project I may not use R scripts to do the log likelihood profiling because it specifically aims to compare PsN functions with another algorithm. Thank you very much in advance for your help. Kind regards, Olga Teplytska Olga Teplytska - Pharmacist - Pharmaceutical Institute - Clinical Pharmacy - An der Immenburg 4 Room 3.109 D-53121 Bonn Phone: +49-(0)228-735242 E-Mail: [email protected] / [email protected] www.klinische-pharmazie.info PsN_llp_plot_V2.pdf Description: Adobe PDF document