Covariates interpretation pre-ACoP workshop

Dear NMusers, In connection with ACoP13 in Aurora, Colorado, October 30-November 2, 2022, Pharmetheus will offer a pre-conference workshop for those of you who have an interest in leveraging NONMEM results when it comes to communication of the impact of covariates; please find some information below. *Forest plots in practical use: Implementation and interpretation* October 30, 2022, 1-day workshop Workshop overview: Forest plots can be used to efficiently summarize the impact of covariates and other predictors on the primary and secondary parameters from population pharmacokinetic and pharmacodynamic models. They can also be used to illustrate the outcome in important patient subgroups and relate the outcome to observed or hypothetical reference subjects. Forest plots are recommended by regulatory authorities and are becoming a standard component of submission packages to the FDA and other regulatory agencies. The goals of the workshop are: - To get an in-depth understanding of how Forest plots should be interpreted given the variations in which point estimates and uncertainties can be derived and reference conditions can be set up. - To learn how to create Forest plots in R based on output from different types of models and covariate modeling techniques. - To get clarity on how Forest plots depend on the underlying modeling methodology and how “Full Model-like inference” can be obtained even from modeling approaches that generate parsimonious covariate models. Workshop faculty: Niclas Jonsson, Ph.D. Joakim Nyberg, Ph.D. More information and registration: https://pharmetheus.com/2022_october_forest_acop_workshop/ https://pharmetheus.com/2022_october_forest_acop_workshop/ We look forward to seeing many of you there and to engage with you on this exciting topic! Best regards, The Pharmetheus Team --- Pharmetheus AB Uppsala Science Park Dag Hammarskjölds väg 36b 75237 Uppsala, Sweden www.pharmetheus.com -- *This communication is confidential and is only intended for the use of the individual or entity to which it is directed. It may contain information that is privileged and exempt from disclosure under applicable law. If you are not the intended recipient please notify us immediately. Please do not copy it or disclose its contents to any other person.* *Any personal data will be processed in accordance with Pharmetheus' privacy notice, available here https://pharmetheus.com/privacy-policy/.** *