Re: OFV by endpoint of joint models?
Hi Matt,
That would work in case you had one subset of subjects with observations of one
endpoint, and another subset of subjects with observations of a different
endpoint - e.g. one study with only PK samples and another study with only PD
samples.
But in such a setting there would not be much value in joint modelling
(simultaneous estimation of the two models), since no subject has observations
of both endpoints.
Or maybe I missed your point?
Best regards
Jakob
Jakob Ribbing, Ph.D.
Senior Consultant, Pharmetheus AB
Cell/Mobile: +46 (0)70 514 33 77
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www.pharmetheus.com
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Quoted reply history
> On 10 Oct 2022, at 17:02, Matthew Fidler <[email protected]> wrote:
>
> Hi Matts,
>
> You can use the table item OBJI and sum over each ID to get any subset you
> want.
>
> Matt
>
>
>
> On Mon, Oct 10, 2022, 9:12 AM Matts Kågedal <[email protected]
> <mailto:[email protected]>> wrote:
> Hi all,
> I have a question related to the objective function value when multiple
> endpoints are modelled jointly. Specifically I would like to know if a change
> in in OFV between models is driven primarily by one of the endpoints or if
> both contributes to the change, or maybe they are even driving the OFV in
> oposite directions.
>
> Is there a way to get some form of partial OFV by endpoint?
> Best regards,
> Matts
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