Postdoctoral Position in Pharmacometrics at The Ohio State University

Hi Everyone, We have an open position for a postdoctoral trainee in pharmacometrics at The Ohio State University. Information on the position and links are provided below. If you are interested, please complete the application process and submit your CV online at https://urldefense.com/v3/__https:/osu.wd1.myworkdayjobs.com/OSUCareers/job/Medical-Center-Campus/Post-Doctoral-Scholar_R40551__;!!KGKeukY!kBOnJygL18bBZ3fSvYgdAVLOvZ_S8zWTUFJ2M4Zgo4pYpZGAHzihg0IglNdTrQIn8A$ Sincerely, Mitch Phelps, PhD Professor, Division of Pharmaceutics and Pharmacology College of Pharmacy Director, Pharmacoanalytical Shared Resource Comprehensive Cancer Center The Ohio State University 506 Riffe Building 496 W. 12th Ave., Columbus, OH 43210 614-688-4370 [email protected]<mailto:[email protected]> The Ohio State University Comprehensive Cancer Center is seeking a postdoctoral researcher to learn and apply pharmacometrics and clinical pharmacology methodologies in cancer-focused research. This position will support pharmacometrics efforts, including quality control of pharmacology data, data analysis, population and PBPK/PD modeling and simulation, and PK/PD study design for human clinical trials and also, to a lesser extent, for non-clinical pharmacology studies conducted in animals. A majority of this activity will be in support of National Cancer Institute sponsored clinical trials through UM1 and U24 grants, and other portions of this activity will support investigator-initiated trials and other NIH-funded and industry-sponsored research. These studies involve the clinical and pre-clinical development of novel anti-cancer therapies, both small and large molecule, and novel drug combinations, as well as characterizing the mechanisms of resistance to FDA approved agents. These activities of the successful candidate for this position will aim to characterize pharmacokinetics, pharmacodynamics or the relationship between both (PK/PD) of small and large molecule anti-cancer agents using statistical modeling approaches to enable further simulation and prediction either within or beyond the study population evaluated. Intensive literature research will be required to understand the current state of knowledge on specific drugs’ PK and PD properties and on state-of-the-art approaches for study design optimization, dose individualization, and PK/PD modeling and simulation. Frequent interactions with PhASR users, including hematologists, medical oncologists, clinical research staff, and other basic and translational scientists will occur to enable appropriate study-design and fit-for-purpose modeling efforts. The successful candidate will have a PharmD or PhD in pharmacology, statistics, engineering, or related field and specific training, experiences, and a demonstrated track record in applying modeling and simulation tools, such as NONMEM, R, Phoenix and/or other related programs, toward clinical and/or preclinical pharmacology studies in popPK/PD, PBPK-PD, and/or QSP approaches. Development of web-based tools and web interfaces for PK/PD model parameter estimation and simulation are a plus. Excellent record-keeping and written and oral communication skills are required, as this position will be responsible for communicating their methods, results and interpretations in reports, manuscripts, grant proposals, as well as in oral presentations in research meetings and at national conferences. The successful candidate will also develop SOPs and train other research staff or students in pharmacometrics methodologies. Interested candidates may apply at the following link https://urldefense.com/v3/__https:/osu.wd1.myworkdayjobs.com/OSUCareers/job/Medical-Center-Campus/Post-Doctoral-Scholar_R40551__;!!KGKeukY!kBOnJygL18bBZ3fSvYgdAVLOvZ_S8zWTUFJ2M4Zgo4pYpZGAHzihg0IglNdTrQIn8A$ Additional information regarding research in The Ohio State University Comprehensive Cancer Center and College of Pharmacy can be found here: https://cancer.osu.edu/for-cancer-researchers https://pharmacy.osu.edu/research