RE: Time-varying input/flexibility to change input rate on the fly

Hi Robin, I don't think that I've seen an update. That said, the need I had then was for a very specific need for an unusual drug. I've only seen this type of issue once where it seemed to need time-dependent effects. Generally, effects similar-- but not identical-- to what I was experiencing at the time are better-modeled with simpler systems. For example, adsorption to infusion sets can almost always be modeled as a decrease in bioavailability and/or a lag time (it's not typically time-dependent behavior). I would assume that loss of part of a tablet or detachment of a patch could be simply modeled as random variability (or a fixed effect) on bioavailability. Random pump malfunction would depend on how it malfunctioned, but I would be wary of trying to model random effects as this more complex time-dependent bioavailability unless you had data on the malfunction method-- in which case I would suggest putting it into the dataset as a different dosing record. Thanks, Bill