Re: Problem with PSN4. 9 - COVARIANCE STEP ABORTED
Dear Shankar,
I think you will need to go deeper into the configuration and settings, as well
as to the directories where NONMEM was actually run, to answer this question.
Here are some things that you can consider:
Did you run both PsN versions using the same nonmem version?
If termination was not successful, was PsN (execute) set up to try again with
another set of initial estimates, and if it was: did you use the same seed when
running execute-4.8 and execute-4.9?
The control streams created by PsN (located in the NM_run1 directory): are they
identical? In this directory you will find e.g. psn.mod. If on a LINUX system
you can just run diff or ’sdiff -s’ to compare this file between the two runs
with execute
Did you change anything else in the configuration of PsN or NONMEM, e.g. the
compiler?
Best wishes
Jakob
Jakob Ribbing, Ph.D.
Senior Consultant, Pharmetheus AB
Cell/Mobile: +46 (0)70 514 33 77
[email protected]
www.pharmetheus.com
Phone, Office: +46 (0)18 513 328
Uppsala Science Park, Dag Hammarskjölds väg 36B
SE-752 37 Uppsala, Sweden
Quoted reply history
> On 3 May 2021, at 18:45, Shankar Lanke <[email protected]> wrote:
>
> Dear NMUsers,
> I am having trouble with PSN4.9, if anyone has a similar issue may I know how
> to fix it?
> I ran a model that was developed prior to the release of PSN4.9. In PSN4.9
> the covariance step is aborted because S Matrix is unobtainable. I purged 4.9
> and loaded 4.8, the model ran perfectly and matched the previous results.
> Thank you very much in advance.
>
> Version 4.9
> #TERE:
> Elapsed estimation time in seconds: 633.22
> 0S MATRIX UNOBTAINABLE
> 0COVARIANCE STEP ABORTED
> Elapsed covariance time in seconds: 47.98
> Elapsed postprocess time in seconds: 51.79
>
> Version 4.8
> #TERM:
> 0MINIMIZATION SUCCESSFUL
> NO. OF FUNCTION EVALUATIONS USED: 783
> NO. OF SIG. DIGITS IN FINAL EST.: 2.0
>
> Regards, <>
> Shankar Lanke
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