ISAMPLE in SAEM algorithm with ETASAMPLES=1
Dear all,
I'm using SAEM algorithm with option ETASAMPLES=1 ISAMPLE=10 EONLY=1 to draw
random eta samples from individual posteriors, according to the NONMEM user
guide. However, I realized that ISAMPLE can not be larger than 10 otherwise
NONMEM will generate only two samples per individual as if ISAMPLE=2. I was
wondering if there's way if I wish to have for instance 50 ISAMPLES?
Additionally, in the example from the NONMEM user guide of using ETASAMPLES=1
EONLY=1, NBURN is set to 200. From my understanding, for such purpose, SAEM
uses parameter estimates from previous $EST step and only draws random samples
around them and there's no maximization step. I guess NBURN=1 would be
sufficient?
Any comment is appreciated!
Warm regards,
Tingjie Guo