ISAMPLE in SAEM algorithm with ETASAMPLES=1

From: Tingjie Guo Date: October 07, 2020 technical Source: mail-archive.com
Dear all, I'm using SAEM algorithm with option ETASAMPLES=1 ISAMPLE=10 EONLY=1 to draw random eta samples from individual posteriors, according to the NONMEM user guide. However, I realized that ISAMPLE can not be larger than 10 otherwise NONMEM will generate only two samples per individual as if ISAMPLE=2. I was wondering if there's way if I wish to have for instance 50 ISAMPLES? Additionally, in the example from the NONMEM user guide of using ETASAMPLES=1 EONLY=1, NBURN is set to 200. From my understanding, for such purpose, SAEM uses parameter estimates from previous $EST step and only draws random samples around them and there's no maximization step. I guess NBURN=1 would be sufficient? Any comment is appreciated! Warm regards, Tingjie Guo
Oct 07, 2020 Tingjie Guo ISAMPLE in SAEM algorithm with ETASAMPLES=1
Oct 08, 2020 Robert Bauer RE: ISAMPLE in SAEM algorithm with ETASAMPLES=1
Oct 08, 2020 Tingjie Guo Re: ISAMPLE in SAEM algorithm with ETASAMPLES=1