RE: How to calculate confidence interval (CI) and prediction interval (PI) of individual prediction (IPRED) in NONMEM

Hi Sam, As far as I know, the simple answer is yes. You just have to specify a CMT data item for each dose to match the $MODEL record numbering of the compartments and the rate constants used by ADVAN5 and ADVAN7. In principle you can have as many doses as you want administered to any compartment at the same time and to multiple compartments at the same time. You have to specify a dosing record for each dose and each compartment. There may be an internal NONMEM limit but I am not aware of one. Best wishes, Nick -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72 email: [email protected] http://holford.fmhs.auckland.ac.nz/ http://orcid.org/0000-0002-4031-2514 Read the question, answer the question, attempt all questions