Re: Block SIZE with SCM

On 2019-12-09 09:04, Emeric Sibieude wrote: Dear Jakob, Thank you for your answer. According to PsN documentation PD = -100 means at least 100 covariates. I tried with the exact number of covariates (PD = 105) and I have the same issue. Yes indeed, I can do it with the default value of PD = 50 because less than 50 are added but I was wondering if there exists a way if more than 50 covariates are added during the forward path. Best Regards, Emeric Sibieude Student trainee in Master's degree Biopharma | R&D | Global Development | Translational Medicine Merck Lausanne , Switzerland [email protected]<mailto:[email protected]> From: Jakob Ribbing <[email protected]><mailto:[email protected]> Sent: jeudi 5 décembre 2019 09:11 To: Emeric Sibieude <[email protected]><mailto:[email protected]>; [email protected]<mailto:[email protected]> Subject: Re: [NMusers] Block SIZE with SCM Dear Emeric, The code has negative PD, maybe PsN has problems interpreting this? I am not sure how PD=-100 would be interpreted by NONMEM, but try PD=100, instead. I think this is what you intended to do? As a side note, PsN (mainly to handle old nonmem versions) has functionality for dropping (=DROP) covariates on $INPUT, if they are not tested in the current model during SCM - but only among the ones listed in the configuration as covariates. Even if you test 50 covariates, it is not often more than ten different will be included during forward inclusion, so possibly you can do with the default PD=50? Best wishes Jakob On 5 Dec 2019, at 08:39, Emeric Sibieude <[email protected]<mailto:[email protected]>> wrote: Dear NMUsers, I am performing scm with PsN. My data have more than 50 covariates, this should be processed by $SIZES PD=100 at the beginning of the NONMEM file. However, it seems that scm command modifies this file by putting the block $PROBLEM at the first line. Here is the beginning of my code : $SIZES LVR=150 PD=-100 SPROBLEM empty model $DATA ID TIME AMT EVID DV CAT1 CAT2 ... Here is the code transformed in the LST file $SIZES LVR=150 PD=-100 $PROBLEM empty model $DATA ID TIME AMT EVID DV CAT1 CAT2 ... And at the end I have the following error NM-TRAN MESSAGES AN ERROR WAS FOUND IN THE CONTROL STATEMENTS. AN ERROR WAS FOUND ON LINE 1 AT THE APPROXIMATE POSITION NOTED: $SIZES LVR=150 PD=-100 $PROBLEM empty mod X THE CHARACTERS IN ERROR ARE: $ 20 UNKNOWN OPTION. Note that this is an issue for estimating the base model only. During the forward path scm automatically drops the unnecessary covariates keeping only the ones added at previous steps and the tested one. First estimate the base model and use the option -base_ofv seems to work however I will have the same issue if more than 50 covariates are added during the forward path. Thank you in advance for any help or any suggestions. 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