Re: Lognormal survival in NONMEM?
Dear Rik,
There are very nice code examples (for NONMEM) in this poster-material from
Nyberg et al.:
https://www.page-meeting.org/pdf_assets/404-Poster_PAGE%20_2014_tte_sim_joakim_nyberg_with_code.pdf
https://www.page-meeting.org/pdf_assets/404-Poster_PAGE%20_2014_tte_sim_joakim_nyberg_with_code.pdf
These include the log-normal distribution, as well as Gompertz and Weibull.
Best regards
Jakob
Jakob Ribbing, Ph.D.
Senior Consultant, Pharmetheus AB
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Quoted reply history
> On 29 Aug 2019, at 15:33, Rik Schoemaker <[email protected]> wrote:
>
> Dear all,
>
> Playing with repeated time to event models, I run into the issue that simple
> diagnostics for a single time to event outcome suggest that constant hazard
> and Weibull models are not very appropriate. The lognormal model seems to
> provide a very nice fit; compared to a constant hazard, the hazard is
> suggested to be higher in the beginning and then significantly lower at later
> times.
>
> I have not seen any implementations online: does anyone know if the lognormal
> survival function can be implemented in NONMEM, and/or can anyone suggest
> alternative approaches? Some time-varying function to modify the hazard?
>
> Any and all suggestions appreciated!
>
> Kind regards,
>
> Rik
>
>
>
> Rik Schoemaker, PhD
> Occams Coöperatie U.A.
> Malandolaan 10
> 1187 HE Amstelveen
> The Netherlands
> www.occams.com http://www.occams.com/
> +31 20 441 6410
> [email protected] <mailto:[email protected]>
>
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