Re: Simulation error

> On Apr 22, 2019, at 8:56 AM, Leonid Gibiansky <[email protected]> > wrote: > > Nonmem needs to allocate memory for all variables stored in the MSF file. For > that, it counts THETAs and ETAs and SIGMAs in the control stream. If some of > them are not listed (often we do not need all parameters of the model for a > specific simulation), one needs to tell the program how much memory is needed > (e.g., $SIZES LTH= 7 LVR= 2) > > One can always keep all THETAs and OMEGAs in the controls stream, for example > by adding dummy variable (in the ERROR block) > TEMP=THETA(5)+ETA(3)+EPS(2).... > listing all unused parameters (or all parameters) > > The second problem is related to the absence of one of the MSF files. MSF > options actually reads two files, FILENAME.MSF and FILENAME_ETAS.MSF. Both > should be in the same file path specified in the control stream for > FILENAME.MSF file. > > Leonid > > > > >> On 4/20/2019 11:11 AM, Ayyappa Chaturvedula wrote: >> Dear All, >> I am trying to run a simulation using $MSFI option instead of giving $THETA >> and $OMEGA. One of the model gave the following error and a recommendation: >> F_LVR AND/OR F_LTH ARE TOO SMALL TO DEAL WITH INPUT FROM MSFI FILE. >> RECOMMEND INSERTING AS FIRST LINE OF CONTROL STREAM: >> $SIZES LTH= 7 LVR= 2. >> I changed the control file with the recommended $SIZES LTH= 7 LVR= 2 as >> first line in the control file. But, then I get the following error message: >> WARNING: EXTRA MSF FILE COULD NOT BE OPENED: msf2_ETAS >> *** Error in `./nonmem': malloc(): memory corruption: 0x000000000400f470 *** >> I appreciate any help resolving this issue. >> Regards, >> Ayyappa