PBPK modeling opening

Scientist/Sr. Scientist opening in the US. Ideal location is in southern CA, but remote will also be considered. Please email me at [email protected]<mailto:[email protected]> for more info * Analyze and interpret preclinical and clinical data. Study the effect of diseases on animal and/or human physiology. Conduct research to further understand the effects of healthy and disease states on drug absorption, distribution, and elimination. * Use mechanistic, physiologically-based pharmacokinetic (PBPK) modeling and simulation approaches to integrate knowledge of pharmacokinetics, pharmacodynamics, efficacy, safety, patient demographics, and pathophysiological factors. * Perform mechanistic absorption/PBPK modeling and simulation to address objectives with client projects, including, but not limited to, FIH predictions, formulation design/optimization, population simulations, and DDI predictions. * Construct and validate mechanistic mathematical models for description of compound distribution in different tissues/organs in the body. * Write study proposals, study reports, and/or white papers to clearly describe model development and validation. * Discuss software applications with clients and prospects on telephone or in person. * Share research findings by writing scientific articles and/or presenting at scientific conferences. Requirements: * Ph.D. or Master's degree (or equivalent) in Pharmaceutical Science, Biostatistics, Biomedical Engineering, or related fields. * Minimum of three (3) years' experience as Scientist, Research Associate, or related. (will consider at a higher level if someone is qualified) * Experience should include performing PBPK modeling of distribution of compounds in animals and humans. It should also include performing PBPK/PD analyses of clinical data, including drug absorption, drug-drug interaction, metabolic stability, clearance, and protein binding. * Excellent oral and written communication skills. * Demonstrates and communicates a positive attitude while interacting with colleagues and clients at all levels. * Must be able to multitask and have strong organizational skills. * Self-motivated with ability to work with minimal supervision. Job Location: southern CA or remote [cid:[email protected]] Brenda Roseberry Division Manager-Scientific Preclinical/Clinical--PK, Pharmacology, Pharmacometrics, Biomarkers 720-328-9526 - Office 315-415-4353 - Mobile 720-475-1176 - Fax [cid:[email protected]] http://www.linkedin.com/profile/view?id=19937880&authType=name&authToken=b5d_