Re: PopPK modelling of DDIs
Hi Pieter,
We did a similar analysis recently on the interaction between
ritonavir/darunavir, published in JAC by Stein Schalkwijk
https://academic.oup.com/jac/advance-article-abstract/doi/10.1093/jac/dky567/5304685?redirectedFrom=fulltext
It is hard to separate covariance in inter-individual variability from the drug
interaction. You’ll have to make some assumptions or have data on both drugs
without the interaction present.
Happy to share my thoughts if necessary.
Cheers,
Rob
Quoted reply history
Op 17 apr. 2019 om 14:39 heeft Pieter Colin
<[email protected]<mailto:[email protected]>> het volgende geschreven:
Dear colleagues,
We are working on a model to describe a pharmacokinetic drug-drug interaction
between two drugs.
I recall that in the past there has been a discussion on the forum about
simultaneously modelling two different drugs for the sake of sharing covariates
or covariate models between them.
Beyond those posts and a paper by van der Laan (AAC 2018) on a
lopinavir-ritonavir DDI, I cannot find published (coding) examples of how to
approach DDIs in a joint PK model.
Hopefully some of you are willing to point us into the right direction?
Best regards,
Pieter Colin
Pharm.D., Ph.D.
Department of Anesthesiology (EB32)
University Medical Center Groningen, The Netherlands
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