Re: In covariate analysis, should we use p-value or OFV to decide which model is better when comparing?

Dear Sumeet, I assume Pirana is merely running PsN, and you can find good documentation for each PsN program, in the PsN documentation: https://uupharmacometrics.github.io/PsN/ https://uupharmacometrics.github.io/PsN/ For this specific question, you should probably not use the gof option and instead specify p-values for forward and backward selection. The gof option is only used in special cases, where one does not want to assume that delta-OFV follows a chi-square distribution (or if one wants to use p-values lower than 0.00000001). Best regards Jakob Jakob Ribbing, Ph.D. Senior Consultant, Pharmetheus AB Cell/Mobile: +46 (0)70 514 33 77 [email protected] www.pharmetheus.com http://www.pharmetheus.com/ Phone, Office: +46 (0)18 513 328 Uppsala Science Park, Dag Hammarskjölds väg 52B SE-752 37 Uppsala, Sweden This communication is confidential and is only intended for the use of the individual or entity to which it is directed. It may contain information that is privileged and exempt from disclosure under applicable law. If you are not the intended recipient please notify us immediately. Please do not copy it or disclose its contents to any other person.