Global Head of Drug Metabolism and Pharmacokinetics at GSK

Global Head of Drug Metabolism and Pharmacokinetics (DMPK) GlaxoSmithKline USA - Pennsylvania - Upper Providence UK - Stevenage Tres Cantos SEE: www.gsk.com_en-2Dgb_careers_&d=DwMGaQ&c=jqQLr8Vjrh9vQZQBMH8t0g&r=ySOb5FWtD_f91znXD7gQYQtPh-qC-wMwIR9nKeMM034&m=zVOlWBpK8TOFcgrrLyeUBLvg9RlLKnUH-R2BfJQK7W0&s=UwoHtFs_POCRuRT_L3_9nzx57G6Rn-tZEsZe2rejvYc&e=">https://urldefense.proofpoint.com/v2/url?u=https-3A__www.gsk.com_en-2Dgb_careers_&d=DwMGaQ&c=jqQLr8Vjrh9vQZQBMH8t0g&r=ySOb5FWtD_f91znXD7gQYQtPh-qC-wMwIR9nKeMM034&m=zVOlWBpK8TOFcgrrLyeUBLvg9RlLKnUH-R2BfJQK7W0&s=UwoHtFs_POCRuRT_L3_9nzx57G6Rn-tZEsZe2rejvYc&e= (posting # 194716, or you can search by "DMPK"). As the VP, DMPK you will provide single point accountability for developing and embedding a unified and integrated global DMPK vision and strategy to ensure the delivery of consistent, reusable DMPK data supporting the efficient and effective progression of Discovery and Development projects, inclusive of Research, Oncology and Global Health. This integrated global strategy will require a focus on leadership, science, technology and culture. Reporting to the SVP, In Vitro/In Vivo Translation, IV/IVT provides expertise in nonclinical models, bioimaging, DMPK, bioanalysis, biomarkers, immunogenicity, safety, and drug disposition in support of nonclinical and clinical studies spanning target identification through post-approval of medicines. As the VP, DMPK you will be integral in taking forward what has already been done with regards to the new structure and look to operationalise and develop the ways of working for this newly consolidated group. You will be responsible for ensuring the organisation is future-proofed and look at ways to modernise, including the greater use of technology and automation. You will also be tasked with developing DMPK scientific experts to define the appropriate data requirements required by projects and influence progression, decision making, and regulatory approvals. These data sets are essential for lead optimization, candidate selection, human pharmacokinetic and dose prediction, as well as clinical drug-drug interactions and dose adjustment for special populations. In this role you will need to build and maintain strong relationships with a number of internal stakeholders including the Research Units, Medicinal Chemistry, Product Development & Supply, and Data & Computational Sciences, Clinical Pharmacology and Experimental Medicine, Development and Regulatory Affairs, as well as with external organisations (academic, CROs, technology firms). You will be required to provide scientific and managerial leadership to an experienced global DMPK function (c. 100 FTEs) spanning the US, UK and Spain, to ensure best practice, focused decision making, execution of key deliverables including the implementation of innovative technologies and approaches to enhance scientific impact and drive efficiency, enhance the depth and breadth of key technical skills focused on project delivery and to develop DMPK scientists at all levels to retain and attract talent. Responsibilities: *Develop a unified vision and strategy for the Global DMPK function in support of R&D objectives *Develop and implement DMPK scientific strategies (including PBPK, PKPD) to deliver earlier robust human PK and dose estimates and to appropriately characterize drug Absorption, Distribution, Metabolism, and Elimination (ADME) *Develop and implement outsourcing strategies to meet programme and project needs *Provide scientific and managerial leadership to a global DMPK function to ensure execution of key deliverables to the entire R&D portfolio with effective people and capital resource allocation across sites *Implement innovative technologies and approaches to enhance scientific impact and drive efficiencies *Build strong collaboration and effective interfaces with all Research Units, Medicinal Science & Technology (especially Medicinal Chemistry, Product Development & Supply, and Data & Computational Sciences), other lines within IVIVT, Clinical Pharmacology and Experimental Medicine, Development and Regulatory Affairs, as well as with external organizations (academic, CROs, technology firms). *Ensure timely completion of DMPK contributions to internal dossiers and regulatory submissions Technical Skills & Experience *PhD or equivalent in Drug Metabolism and Pharmacokinetics or related discipline *Knowledge of Discovery and Development DMPK. Ability to assess drug developability *Significant experience in drug discovery and development with a deep scientific and strategic expertise in cross functional interdependencies. *Track record in leading a multidisciplinary DMPK function. Competencies *Proven ability to influence, communicate and negotiate with all levels of management across functional and business unit boundaries *Excellent oral & written communication and presentation skills *High mental and people agility *Ability to build strong relationships across broad stakeholders. *Design and implement a plan to recruit, develop and retain key talent to maintain a high-performing team GSK monitors email communications sent to and from GSK in order to protect GSK, our employees, customers, suppliers and business partners, from cyber threats and loss of GSK Information. GSK monitoring is conducted with appropriate confidentiality controls and in accordance with local laws and after appropriate consultation.