Re: Easier IOV modeling

Hi Sebastien, Interesting notion, thanks. It should be possible from NM7.3 onwards using MOD or DECLARE as described in the sections just below the one you referenced. With DECLARE it could look like this: $ABBR DECLARE INTEGER IOCC $PK CALLFL=-2 IF (NEWIND < 2) IOCC=0 IF (AMT > 0 .and. CMT==1) THEN IOCC = IOCC + 1 ENDIF IF (IOCC>MAXOCC) IOCC = MAXOCC ; define MAXOCC in the dataset or in code to prevent referencing more than defined in $OMEGA ... IOVCL = ETA( 1 + IOCC*3 ) ; first dose occasion will get assigned eta(4) as below, than 7, 10 etc... CL = TVCL * EXP( ETA(1) + IOVCL ) And using MOD on TIME, assuming regular nominal daily dosing, it could look like: $ABBR DECLARE INTEGER IOCC $PK IOCC = ( TIME - MOD( TIME, 24) )/24 + 1 ; assume TIME in hours and starting at zero IOVCL = ETA( 3 + IOCC*3 ) ; first day will get assigned eta(4) as below, than 7, 10 etc... CL = TVCL * EXP( ETA(1) + IOVCL ) And therefore I think it could be possible indeed. I however do not think it is easier, and I see OCC coding in the dataset as more robust. But in cases where it is not possible to modify the dataset, such an approach might be an option. As a reclaimer: the above code snippets are heavily leaning on the userguide examples and completely untested. Please test before use. Hope this helps, Jeroen http://pd-value.com [email protected] @PD_value +31 6 23118438 -- More value out of your data!