PhD Studentship - Model-based precision dosing of levofloxacin in critically ill patients, University of Manchester

(MRC DTP) Model-based precision dosing of levofloxacin in critically ill patients University of Manchester | Faculty of Biology, Medicine and Health | Manchester | United Kingdom Dr A Darwich, Dr K Ogungbenro, Dr T Felton Application Deadline Friday, November 16, 2018 Project Description Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality in adults and children worldwide1. In the UK, CAP accounts for over 100,000 hospital admissions annually. Levofloxacin is a broad spectrum antibiotic licenced for the treatment of CAP. Resistance of levofloxacin is increasingly identified in patients with CAP. The current, fixed dose of levofloxacin was established in early phase trials of healthy volunteers and non-critically ill patients. Antibiotic pharmacokinetics has been demonstrated to be different in critically ill patients compared to healthy volunteers with marked between subject variability. Between-subject variability results in under-dosing and treatment failure in a significant proportion of patients. The optimal dose of levofloxacin in critically ill patients with CAP is still not clearly defined. The objective of this project is to develop a model-based precision dosing algorithm for levofloxacin in critically ill patients to improve treatment outcome, using mechanistic model that account for between-subject variability in the pharmacokinetics. https://www.findaphd.com/search/ProjectDetails.aspx?PJID=101627 Kay Kayode Ogungbenro, PhD Lecturer in Cancer Pharmacometrics | Division of Pharmacy and Optometry | School of Health Sciences The University of Manchester | Manchester M13 9PT | United Kingdom Tel : + 44(0)161 275 2399 Fax: +44(0)161 275 8349 Email: [email protected]<mailto:[email protected]> Web: http://www.pharmacy.manchester.ac.uk/staff/18015