10th Advanced course on Pharmacometrics

Dear Members, Don't miss this exciting opportunity to learn novel pharmacometrics approaches for improving the efficiency of drug development. PharmacoMetrica is holding the: 10th Advanced course on Pharmacometrics November 5-8, 2018: Chateau de Longcol (France) This is a 3-day course designed to present advanced concepts on pharmacometrics using novel methodologies based on integrated drug-disease-trial models, surface response analysis and clinical trial simulation. Case studies are presented to illustrate how these tools can be used for improving the decision-making process during drug development, for facilitating the development and use of predictive models for describing complex PK profiles, in-vitro/in-vivo correlation, and exposure-response relationships in presence of confounding factors such as placebo effect and tolerance. Course objectives To present concepts and practical solutions for: Advanced PK modeling * To characterize the complex in-vivo absorption processes of extended release formulations (ER) and Long Acting Injectable (LAI) formulations using convolution-based approach * To evaluate In-Vitro/In-Vivo correlation methods, including convolution-deconvolution approach Advanced exposure-response modeling * To evaluate the relationship between drug exposure and clinical response * To develop models accounting for the confounding role of time varying placebo response in the assessment of the clinical response * To develop integrated disease-drug-trial models * To handle acute tolerance effect * To estimate the probability of clinical benefit of a treatment Optimizing drug performances * To implement drug optimization strategies using surface-response analysis * To determine the relationship between drug delivery and clinical benefit * To determine dose, dosage regimen and dosing strategies for optimizing the clinical benefit Course material The R scripts (including Shiny based applications) used in the hands-on sessions and the NONMEM control streams will be distributed to the participants. The material includes: o the convolution/deconvolution analysis, o the clinical trial simulator for describing the clinical response in presence of placebo and active drug response, o the estimation of the optimal in-vitro dissolution profiles o the convolution/deconvolution analysis, o the non-linear optimizer used in the surface-response analysis Venue: Chateau de Longcol (France): http://www.chateadelongcol.com/ http://www.chateadelongcol.com/ Additional details are available at: http://pharmacometricaworkshop.webs.com/ http://pharmacometricaworkshop.webs.com/ Roberto Gomeni, PhD PharmacoMetrica Longcol, 12270 La Fouillade (France) http://www.pharmacometrica.com/ www.pharmacometrica.com Next workshop: http://pharmacometricaworkshop.webs.com/ http://pharmacometricaworkshop.webs.com/