M&S Summer Internship at Allergan

The Pharmacometrics/Modelling and Simulation discipline at Allergan is seeking a summer intern for 2018. The incumbent will be working under the direction of an M&S scientist to develop an ocular PBPK model to support research and translational science. The incumbent will be using a large database of ocular tissue and serum PK data across many different investigational drugs along with their physicochemical properties to establish and validate a mechanistic model with predictive capabilities with the intent to support future study designs and reduce animal use in alignment with our corporate 3R objectives. Experience in the following areas is a plus: PBPK, nonlinear-mixed effects modelling with working knowledge NONMEM, WinNonlin, SAS and/or R programming. Key responsibilities: * Develop and validate a predictive PBPK model * Mining Allergan internal, and if necessary, literature ocular PK data * Organize and program datasets to make them amendable for modelling * Perform data visualization * Create a centralized repository folder to store the data and model * Present data to group and symposium at the end of the program The incumbent may attend project team and group meetings to gain industry/project-support experience Qualifications * B.S. or equivalent degree is required * The ideal candidate is preferred to be enrolled in a doctoral or master's program in one of the following disciplines: pharmacokinetics, pharmacometrics, pharmaceutical sciences, biostatistics, data programming or mathematics. * Must be enrolled as a full-time student at an accredited university and in good academic standing. * Must have valid U.S. work authorization without the need for sponsorship by the company. * Must be able to work full-time for 10 weeks for the duration of the internship. * No relocation, transportation, or housing assistance will be provided Ability to travel up to [0]% of time. Note: While this job description is intended to be an accurate reflection of the job requirements, management reserves the right to modify, add or remove duties from a particular job and to assign other duties as necessary and at any time. Email CV directly to: [email protected] Kenneth T. Luu, PhD Director of Pharmacometrics, Allergan plc 2525 Dupont Dr. Irvine, CA 92610 Tel. 714-246-2803 This e-mail, including any attachments, is meant only for the intended recipient of the transmission, and may be a confidential or privileged communication. If you received this e-mail in error, any review, use, dissemination, distribution, or copying of this e-mail is strictly prohibited. Please notify us immediately of the error by return e-mail and please delete this message from your system. Thank you in advance for your cooperation.