Translational Modeling positions available (Pfizer Location: Cambridge MA)

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives. We are pleased to announce three open positions in Translational Modeling and Simulation within Pharmacokinetics, Dynamics and Metabolism (PDM) of Medicine Design at our Cambridge Massachusetts site. Additional information about each position can be found using the links below or searching Pfizer's career page www.pfizercareers.com&d=BQMFAg&c=UE1eNsedaKncO0Yl_u8bfw&r=IAMxZZ25NJQupcXBcPpG7_-0QQzvAQQrTmJGMtHe53o&m|BulppKqqiSz44qnwBPAtondRj3tw3AGV5IiWbReRs&sQwqbpeZjyAEpFmSRZdOAm6yL6BGLAjhNmT766X_SE&e=">https://urldefense.proofpoint.com/v2/url?u=http-3A__www.pfizercareers.com&d=BQMFAg&c=UE1eNsedaKncO0Yl_u8bfw&r=IAMxZZ25NJQupcXBcPpG7_-0QQzvAQQrTmJGMtHe53o&m|BulppKqqiSz44qnwBPAtondRj3tw3AGV5IiWbReRs&sQwqbpeZjyAEpFmSRZdOAm6yL6BGLAjhNmT766X_SE&e=) using the Job ID's. Job Summaries Senior Scientist: Job ID: 4695549 https://pfizer.wd1.myworkdayjobs.com/en-US/PfizerCareers/job/United-States---Massachusetts---Cambridge/Sr-Scientist--Translational-Modeling-and-Simulation_4695549-1 The successful applicant will have an opportunity to support a range of projects in the Cardiovascular and Metabolic Disease; Inflammation and Immunology and Rare Disease areas. Work will primarily be focused on a range of standard and novel therapeutic modalities relevant to small molecules. Implementing translational science, such as empirical and/or model-based inter-system or interspecies scaling of PK-PD, human dose projections and therapeutic index predictions, will be an important task supporting projects transitioning into the clinic. In the earlier phases of drug discovery, development of mechanistic and/or systems pharmacology models is an essential responsibility for guiding discovery teams to evaluate molecular targets and design appropriate candidate molecules for clinical progression. In addition to portfolio support, the successful applicant will aid biologists and experimentalists in implementing emerging methodologies and technologies with respect to the design, execution and interpretation of in vitro and in vivo pharmacology studies. The successful applicant will have the opportunity to work with multiple stakeholders outside of the modeling and simulation discipline. He/she is also expected to network with global modelers in the Translational Modeling and Simulation as well as other groups (Clinical Pharmacology, Pharmacometrics) to share knowledge, work on collaborative projects and enhance consistency in best practices across sites, disease areas, and therapeutic approaches. The individual is expected to keep up to date with emerging literature and science in modeling and simulation sciences and will have opportunities to present scientific results both internally and externally through conference presentations and publications. Given the global nature of project teams and group members, excellent communication skills, a pro-active approach and independence are essential characteristics for the successful applicant. Senior Principal Scientist: Job ID: 4695884 https://pfizer.wd1.myworkdayjobs.com/en-US/PfizerCareers/job/United-States---Massachusetts---Cambridge/Sr-Principal-Scientist--Molecular-Modeling-and-Simulation_4695884-1 The successful applicant will have an opportunity to support a range of projects primarily in the oncology therapeutic area, covering small molecules and novel modalities (e.g. nanoparticles). Implementing translational science, such as empirical and/or model-based interspecies scaling of PK-PD and making human dose projections, will be an important task supporting projects transitioning into the clinic. In the earlier phases of drug discovery, development of mechanistic and/or systems pharmacology models will be an essential responsibility for guiding discovery teams to select appropriate compounds and molecular targets. In addition to portfolio support, the successful applicant will aid biologists and experimentalists in implementing emerging methodologies and technologies with respect to the design, execution and interpretation of in vitro and in vivo pharmacology studies. The successful applicant will have the opportunity to work with multiple stakeholders outside of the modeling and simulation discipline. He/she is also expected to network with global modelers in Translational Modeling and Simulation as well as other groups (Clinical Pharmacology, Pharmacometrics) to share knowledge, work on collaborative projects and enhance consistency in best practices across sites, disease areas, and therapeutic approaches. The individual is expected to keep up to date with emerging literature and science in modeling and simulation sciences and will have opportunities to present scientific results both internally and externally through conference presentations and publications. Given the global nature of project teams and group members, excellent communication skills, a pro-active approach and independence are essential characteristics for the successful applicant. Research Fellow: Job ID: 4695547 https://pfizer.wd1.myworkdayjobs.com/en-US/PfizerCareers/job/United-States---Massachusetts---Cambridge/Research-Fellow--Molecular-Model-and-Simulation_4695547 The successful applicant will lead a group of 3 PhD-level scientists supporting projects across Pfizer's Cardiovascular and Metabolic Disease; Inflammation and Immunology; and Rare Disease areas. A key accountability is to ensure fit-for-purpose quantitative approaches to human translation across every program within these therapeutic areas. Delivery will require hands on support as well as working through direct reports. A core technical component is the development of mathematical models capable of supporting drug design, candidate selection and early clinical development. The successful candidate will establish productive working relationships with key partner groups including: DMPK, biology, medicinal chemistry, clinical pharmacology, precision medicine and drug safety. To this end, excellent communication skills are required in order to properly motivate work plans; gain alignment; and place results in context for decision making. As a manager and leadership team member, the successful applicant will be responsible for mentorship and career development of junior staff. As a senior discipline leader, the successful applicant is expected to remain abreast of the literature as it relates to translational modeling and simulation and to maintain an external presence through regular publication and/or involvement in discipline-leading external organizations. Equal Employment Opportunity Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. How to Apply To learn more about these exciting opportunities, please visit www.pfizercareers.com&d=BQMFAg&c=UE1eNsedaKncO0Yl_u8bfw&r=IAMxZZ25NJQupcXBcPpG7_-0QQzvAQQrTmJGMtHe53o&m|BulppKqqiSz44qnwBPAtondRj3tw3AGV5IiWbReRs&sQwqbpeZjyAEpFmSRZdOAm6yL6BGLAjhNmT766X_SE&e=.">https://urldefense.proofpoint.com/v2/url?u=http-3A__www.pfizercareers.com&d=BQMFAg&c=UE1eNsedaKncO0Yl_u8bfw&r=IAMxZZ25NJQupcXBcPpG7_-0QQzvAQQrTmJGMtHe53o&m|BulppKqqiSz44qnwBPAtondRj3tw3AGV5IiWbReRs&sQwqbpeZjyAEpFmSRZdOAm6yL6BGLAjhNmT766X_SE&e=. Search for job ID and submit your application online.