Free Workshop
Please join us at the University of Florida College of Pharmacy (Orlando
Campus) on Saturday March 24, 2018 (1:30-5:50 PM) for a free workshop: Case
studies with mrgsolve: PBPK and QSP model implementation and utilization in R.
In this tutorial session, we will review case studies in PBPK and QSP modeling
and simulation using mrgsolve in R. mrgsolve ( https://mrgsolve.github.io) is a
free, open-source modeling and simulation platform to support ODE-based model
development in R.
Outline:
- mrgsolve overview (brief tutorial)
- PBPK model characterizing drug-drug interactions between HMG-CoA reductase
inhibitors and cyclosporine (Yoshikado et al. 2016; PMID 27170342)
- Sensitivity analyses
- Parameter estimation
- Evaluation of combination chemotherapy regimens using a QSP model for MAP
kinase signaling in colorectal cancer (Kirouac et al. 2017; PMID 28649441)
- Create complicated input data sets
- Options for parallelizing simulations
- Discussion
Instructors: Kyle Baron Pharm.D., Ph.D., Matthew Riggs, Ph.D.
Materials Provided by Sponsor: Course slides, data and code for all examples.
Requirements for Attendees: Knowledge and experience in population PKPD
modeling and a laptop with WiFi internet capability.
To register, please visit:
https://www.eventbrite.com/e/case-studies-with-mrgsolve-pbpk-and-qsp-model-implementation-and-utilization-in-r-tickets-43348159512