Unable to achieve Cmax

From: Anuja Dhas Date: December 07, 2017 technical Source: mail-archive.com
Dear All, I am a Beginner for NONMEM. I am having a dataset of oral BE study. The Drug is BCS III and tmax is 0.5-2hrs. I have observed lag time and double peak; but I am not assure it is double peak or sampling error. I have used ALAG in the control file to deal with lag time. The half of the subjects are following 1 compartmental absorption and the rest are following 2 compartmental absorption. So I separately modeling each compartment. Is it right method?? Should I use transit model? The elimination phase is captured well; but I am unable to achieve Maximum Concentration. The CWRES vs. Time & CWRES vs.PRED plots clearly indicates bias at high concentration. Please suggest me some needful actions to deal with these problems. Best Regards Anuja "Disclaimer: Legally privileged confidential information, binding only if confirmed in writing by a person authorized by Cipla. Please notify sender immediately and permanently delete message if you are not intended recipient. This email is an informal communication and not a definitive opinion of the company or the author. Thoughts or ideas expressed here may be incomplete or in error and subject to further review and change. Thank you."
Dec 07, 2017 Anuja Dhas Unable to achieve Cmax
Dec 08, 2017 Martin Bergstrand RE: Unable to achieve Cmax