Unable to achieve Cmax
Dear All,
I am a Beginner for NONMEM. I am having a dataset of oral BE study. The Drug is
BCS III and tmax is 0.5-2hrs. I have observed lag time and double peak; but I
am not assure it is double peak or sampling error. I have used ALAG in the
control file to deal with lag time. The half of the subjects are following 1
compartmental absorption and the rest are following 2 compartmental absorption.
So I separately modeling each compartment. Is it right method?? Should I use
transit model?
The elimination phase is captured well; but I am unable to achieve Maximum
Concentration. The CWRES vs. Time & CWRES vs.PRED plots clearly indicates bias
at high concentration.
Please suggest me some needful actions to deal with these problems.
Best Regards
Anuja
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