Use of ACCEPT in $DATA

NONMEM 7.4.1 Colleagues I am trying to use the ACCEPT option in $DATA in order to select a subset of records (to evaluate the impact of the # of samples/subject on confidence intervals). I used the following code: ACCEPT=(TIME=0, TIME=1, TIME=2, TIME=4, TIME=6, TIME=24) NMTRAN then creates a dataset but — to my surprise — TIME=6 is not in the dataset (all the others are). I am copying the first few rows of the input dataset so that you can see what is being provided to NMTRAN: ID,AGE,MONTHS,SEX,WT,AMT,RATE,TIME,EVID,MDV,REPLICATE,IPRED,CWRES,DV,PRED,RES,WRES 1101,12,144,1,30.054,210.38,841.51,0,1,1,1,0,0,0,0,0,0 1101,12,144,1,30.054,0,0,1,0,0,1,187.42,0,179.28,199.26,-19.979,0 1101,12,144,1,30.054,0,0,2,0,0,1,180.92,0,187.92,194.09,-6.1659,0 1101,12,144,1,30.054,0,0,4,0,0,1,169.84,0,177.66,184.37,-6.712,0 1101,12,144,1,30.054,0,0,6,0,0,1,160.61,0,153.43,175.39,-21.96,0 The underlined / boldfaced value (6) in the final row is the problem. I assume that NMTRAN is reading that value as something other than 6.0 (e.g., 6.000001) and thereby omitting it. I have reviewed NMHELP to see if there is some other way to accomplish this. Ideally, there would be something like: TIME.GT.5.9.AND.TIME.LT.6.1 but that does not appear to be supported. The alternative is to modify the dataset to include many possible MDV/EVID columns. However, it would be more elegant to do this in the control stream. Or, if there is some way to find out the exact value that NMTRAN sees, I could specify that value. Any help would be appreciated. Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone / Fax: 1-866-PLessThan (1-866-753-7784) www.PLessThan.com http://www.plessthan.com/