RE: Two compartment model with fixed omega parameters

Dear Waroonrat, To know if a model “adequately describe the data” you need to study model diagnostics. Read more for example here: http://onlinelibrary.wiley.com/doi/10.1002/psp4.12161/full The AIC numbers in your case indicate that the two compartment model is a much better description of your data than the one compartment model (read on AIC here: https://en.wikipedia.org/wiki/Akaike_information_criterion). However, this is only a relative comparison and as pointed out before does not say anything about whether any of the models “adequately describe the data”. All the best, Martin Bergstrand, Ph.D. Senior Consultant Pharmetheus AB *From:* [email protected] [mailto:[email protected]] *On Behalf Of *Waroonrat Sukarnjanaset *Sent:* Tuesday, June 27, 2017 10:52 AM *To:* [email protected] *Subject:* [NMusers] Two compartment model with fixed omega parameters Dear NMusers, I have tried to find an appropriate base model. I found that two compartment model with fixed Omega of V2 and Omega of Q = 0 (AIC 1860.17) provided smaller AIC than one compartment model (AIC 1921.83) did. >From these findings (no variability on V2 and Q), is it suggesting that one cpt model could adequately describe the data? I would truly appreciate it if you could give me some suggestions. Kind regards, Waroonrat