Re: DEFDOSE/DEFOBS Required for Many Compartments?
Bill,
Here's how it looks to me right now.
I put together a little test case:
$INPUT ID DOSE=AMT TIME CP=DV WT CMT EVID
$MODEL
COMP=(One,INITIALOFF,NODOSE)
COMP=(PKCENT)
I ran this with a data set in which CMT=2 for both dose and observation
records.
PREDPP gives me the same error message that you reported:
DATA REC 1: COMPARTMENT ASSOCIATED WITH THE PREDICTION IS OFF
NMTRAN makes the assignment of "Default for observations"
inappropriately:
COMPT. NO. FUNCTION INITIAL ON/OFF DOSE DEFAULT
DEFAULT
STATUS ALLOWED ALLOWED FOR DOSE FOR OBS.
1 ONE OFF YES NO NO YES
2 PKCENT ON YES YES YES NO
3 OUTPUT OFF YES NO NO NO
The PCMT data item is needed with dose records to identify the
prediction compartment associated with the dose record, and, when PCMT
is not
defined, this is defaulting to "Default for observations," which is
compartment 1,
which is initially off.
The DEFAULT FOR OBS compartment should have the attribute "INITIAL ON".
Your fix is a good one (specify both DEFDOSE and DEFOBS).
Another fix is to supply the PCMT data item in the data set, and (in my
case) set PCMT=2
This is something that can be fixed with a future version of NONMEM (its
too late for 7.4).
-- Alison
Quoted reply history
On Mon, May 1, 2017, at 09:33 AM, Bill Denney wrote:
> Hi,
> I have a model with many compartments (42 different compartments
are defined). It is currently setup this way to future-proof the
dataset in case we want to combine analyses of many drugs (about
20 different drugs with central/peripheral compartments) and
several endpoints.
> In the current model, I'm only fitting the PK of one drug, so
only two of the compartments are enabled: compartments 39 and
42. After the IGNORE statement, the data is relatively small with
400 records between 16 subjects, and all the data are in
compartment 39 (the central compartment for the current drug).
> CMT, EVID, and MDV (along with everything else) is correctly
specified. When I run the model with CMT 39 defined by:
> COMP=(PKCENT) ; 39 central PK compartment (ug/mL)
> the model fails with the error "COMPARTMENT ASSOCIATED WITH THE
PREDICTION IS OFF" noted for all the dosing rows, but when I
specify that compartment 39 is the default observation and dose
compartment (due to IV dosing), the model works.
> COMP=(PKCENT,DEFOBS,DEFDOSE) ; 39 central PK compartment (ug/mL)
> I thought that when CMT and EVID are specified, DEFOBS and
DEFDOSE are not important.
> Does anyone know why adding DEFOBS and DEFDOSE fixed my model?
> Thanks,
> Bill
> Human
Predictions Logo[ http://www.humanpredictions.com/]*William S.
Denney, PhD*
> Chief Scientist, Human Predictions LLC
> +1-617-899-8123
> [email protected]
> This e-mail communication is
confidential and is intended only for the individual(s) or
entity named above and others who have been specifically
authorized to receive it. If you are not the intended
recipient, please do not read, copy, use or disclose the
contents of this communication to others. Please notify the
sender that you have received this e-mail in error by replying
to the e-mail or by calling +1-617-899-8123. Please then
delete the e-mail and any copies of it. Thank you.
--
Alison Boeckmann
[email protected]