The Third Workshop on Non-Linear Mixed Effects Modeling using NONMEM® for Beginners - 2017

The University Hospital of Cologne The Third Workshop on Non-Linear Mixed Effects Modeling using NONMEM for Beginners - 2017 We are delighted to announce our 3-day Third Workshop to Non-Linear Mixed Effects Modeling using NONMEM for Beginners - 2017. This workshop aims to introduce the basic concepts and principles of non-linear mixed effects modeling using NONMEM and other assisting software suites (e.g. PsN, Xpose & Pirana). As part of the workshop, hands-on sessions and case studies will be offered to familiarize the participants with the workflow and technicalities associated with population modeling such as data management, model coding, and interpretation of the results. Target Audience: Pharmacometric analysis is progressively becoming an indispensable tool in drug development and clinical care. The course is intended for participants with limited or basic knowledge of PK/PD modeling who wish to use this tool for informing and rationalizing decisions by introducing them to some of the state-of-art tools in pharmacometrics. Location: The University Hospital of Cologne, Center of Pharmacology, Cologne, Germany. Date: 30th June to 2nd July, 2017 (just after the 14th European ISSX meeting, 26th to 29th June, 2017,see http://issxeuro2017.org/ for details) Instructors: The course will be organized by the Clinical Pharmacology Unit in the University Hospital of Cologne, and tutored by young dynamic tutors (actual and former members of the team) who have demonstrated their solid experience and profound knowledge by numerous publications in international journals and conferences. Through multiple research projects, they have used modeling and simulation to address different questions relevant to drug development and to the clinic. Examples of their work included analyzing data from different sources (preclinical, phases-I, -II & -III studies), of different nature (continuous, categorical and time-to-event), and for different purposes (physiologically-based pharmacokinetics, mechanism-based pharmacodynamics, and survival). Language: English Workshop Outline: * Introduction to (non-)linear regression modeling: basic statistical principles, least squares and maximum likelihood fitting, fixed and random effects, first order (conditional) estimation. * Introduction to population pharmacokinetic modeling: introduction to NONMEM files (control stream and data file), structural model development, random effects modeling. * Model evaluation: introduction to supporting software tools (e.g. R, Xpose, PsN), goodness-of-fit plots, residual diagnostics, bootstrapping analysis, simulation based diagnostics (e.g. visual predictive checks). * Covariate model building * Introduction to modeling pharmacodynamics: different pharmacodynamic models, linking pharmacokinetics to pharmacodynamics Computers will not be provided and therefore we kindly ask you to bring your own laptops with you and we will provide the necessary software on USB sticks. Workshop Fees: * 1200 for participants from industry and commercial enterprises * 600 for academics and participants from non-profit organizations * 300 for students in MSc or PhD programs. For registration: please send an e-mail to max.taubert ax.taubert and instructions for payment will follow as soon as a sufficient number of participants is reached. Please DO NOT make any travel arrangements before we send you back a confirmation. Quoting some of the feedback from previous workshops: Instructors were experienced and well-informed. They were also patient with questions What I really liked about this workshop was the hands-on sessions Material was excellent, and the tutors made an excellent introduction to NONMEM. Max Taubert Department I of Pharmacology Center for Pharmacology Clinical Pharmacology Unit University Hospital Cologne Gleueler Str. 24, 50931 Kln, Germany phone +49 221 478-86716 fax +49 221 478-7011 e-mail max.taubert