RE: Generating TAD with ADDL dosing format
Hi Camila.
If you have access to R, consider the github package "tad" identified below.
It supports calculation of TAD as a column in your dataset, explicitly
considering ADDL. Let me know if you have issues installing or operating. The
following worked for me.
Regards,
Tim
install.packages('devtools')
library(devtools)
install_github('bergsmat/tad')
library(tad)
?tad
example(tad)
Tim Bergsma, PhD
Associate Director
Certara Strategic Consulting
[cid:[email protected]]
m. 860.930.9931
[email protected]<mailto:[email protected]>
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of de Almeida, Camila
Sent: Tuesday, December 20, 2016 6:46 AM
To: [email protected]
Subject: [NMusers] Generating TAD with ADDL dosing format
Hello,
I was wondering if I could get some guidance from this great group. My issue is
primarily with some diagnostic analysis, but this is taking me back to an old
NONMEM problem.
My aim is to run a VPC on a model I implemented, and if possible change the idv
to TAD instead of TIME. The reason for that is the VPC graph based on TIME
looks dreadful as the data is sparse and from different studies of different
lengths.
I'm having issues generating the TAD output column from my NONMEM run. I
naively assumed I could easily do that, but looking at the NONMEM archives it
seems this gets tricky when your dosing events are written using ADDL. Has
anyone ever managed to find a solution for this? And if not, is there an
alternative way to run the VCP on TAD, do we really need to get this column
from NONMEM's output?
Thanks all,
Camila de Almeida, PhD
PKPD Scientist,
Modelling & Simulation, IMED Oncology DMPK
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