Re: Laplacian, BQL and initial estimates
Hi Mark,
Might you have more than one $EST step where Laplacian is not used in one of them? And, can you share your $EST step options?
Thanks,
Bill
Quoted reply history
On 7/17/2016 4:28 PM, Mark Sale wrote:
> Question:
>
> NONMEM has a function to run a grid search to obtain initial estimates for THETA. But, when I try to do this with BQL data/Laplacian I get this run time error message:
>
> 0PROGRAM TERMINATED BY OBJ
> WITH INDIVIDUAL 1 ID= 1.00000000000000E+00 DATA REC. 13
> WITH NMPR17, LAPLACIAN ESTIMATION METHOD MUST BE USED
>
> It seems the Laplacian isn't used for the grid search for initial estimates (even though specified in $EST).
>
> any ideas?
>
> Mark Sale M.D.
>
> Vice President, Modeling and Simulation
>
> Nuventra Pharma Sciences, Inc.
> 2525 Meridian Parkway, Suite 280
> Durham, NC 27713
>
> Phone (919)-973-0383
>
> [email protected] <[email protected]>
>
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