New Release : PDx-Pop 5.2 !!!

Dear NONMEM and PDx-Pop users, As some of you are already aware of, PDx-Pop, a graphical user interface developed by ICON for the NONMEM software, has been with us for the last thirteen years. It has helped many NONMEM modelers with running NONMEM in an organized and efficient way and to visualize the resulting output. A new release of PDx-Pop 5.2 developed by ICON is now available. Here is a short description of the new features, bug fixes, and improvements for the new version. New Product Features from Version 5.1 to 5.2 The following changes have been made to Pdx-Pop5.2, since version 5.1: * User control of Look and File - Users may now define the font size and color palette of the PDx-Pop user interface to accommodate a variety of color tastes, screen sizes, screen aspect ratios, and eyesight ability. * The summary (*.sum) file producer, summary.exe or summary.p, has the ability to interpret short hand inputs for $THETA, $OMEGA, and $SIGMA (such as (0.5 FIXED)x4, VALUES(0.1,0), etc) that were introduced in NONMEM 7.3. * The control stream file wizards have been greatly enhanced. Both the PK Model wizard (for ADVAN 1, 2, 3, 4, 10, 11, and 12) and the User Model wizard (for setting up differential equations ADVAN 6, 8, 9, 13, or multi-compartment linear models ADVAN 5, 7) have been enhanced to allow the addition of classical as well as advanced methods of analysis, and addition of prior information. * The Model/Run tab has enhanced checkboxes for NONMEM command line options, such as -tprdefault -xmloff, -maxlim=1,2,3 modes, or for choosing specific LIM numbers. The -parafile option has been improved upon, allowing the user to select from a general parafiles directory rather than from a project directory, as the selection of a parafile is based on environment, not on project. * Because new command line options for future versions of NONMEM cannot be anticipated at this moment, and there may be user-defined options, such as [nodes]=4, etc., there is now also an "Additional Command Line Options" text box on the Model/Run allowing free-form entry of additional command line options. * The run-time control buttons STOP, NEXT, and ITERATIONS have been improved, so that they may act also in multiple simultaneous jobs conditions, so that the signals are sent to all processes, and the STOP action will cause all processes to terminate gracefully, and not load the next job on the list, if there are any. * The job control in the Evaluations tab has been enhanced to match those of the Model/Run tab, in that command line options, parallelization options, and run-time control buttons (STOP, NEXT, ITERATIONS) have been added. * Several of the Evaluation methods have been parallelized: Initial Parameters Test, Leverage Analysis test, Multiple MCMC Chains parallelization have been enhanced while WAM analysis method, and the Bootstrap analysis have been parallelized. * The Bootstrap Analysis method has been greatly enhanced to allow the more flexible NONMEM bootstrap algorithm to be used, which allows creating separate bootstrap runs on multiple CPUs to be simultaneously executed, with different initial seeds, and all results then compiled to a single boot-runno.prt file, and then submitted for analysis by R/S-Plus scripts. Furthermore, NONMEM bootstrap allows use of stratification information. The Bootstrap tools and scripts have been enhanced to handle occasional failed estimations. * The general file browser/text editor can be immediately accessed from anywhere in PDx-Pop by pressing Ctl-T, allowing a user to inspect any file, by default from the present project directory, but can be maneuvered to other directories. * The Visual Predictive Check algorithms have been enhanced. In addition to the classic Predictive Check script (predcheck), there are now also available Standardized Visual Predictive Check (svpc), sand Prediction Corrected Predictive Check with confidence intervals (civpc). * The OFV profiling algorithm is also now able to handle failed estimations. Bug fixes from PDx-Pop 5.1: The following bugs from PDx-Pop 5.1 have been fixed: * The bootloop.exe and bootloop.pl files supplied with PDx-Pop 5.1 caused an error when the bootstrap evaluation results were displayed in R and S-Plus. * On some Windows 7 platforms and higher, the .prf extension is security protected. This prevents the Bootstrap and OFV Profiling algorithms from working properly in these environments, as these components create and use files with .prf extension for listing results. * For version of R higher than 2.15, the standard deviation assessment code in chainplot.R no longer works and a new code line needed to be updated. * In some Linux versions (especially Ubuntu) of PDx-Pop 5.1, R could not be loaded. The issue has been fixed in PDx-Pop 5.2. If you have any questions about the new version, please do let me know or, if you want to try it out, please email [email protected]<mailto:[email protected]> or call +1-301-944-6810. Happy modeling! With sincere regards, Indrajit Das Scientist 1 Pharmacometrics, R&D Tel: +1-215-583-2872 Email: [email protected]<mailto:[email protected]> Web: http://www.iconplc.com/