Re: Rounding (error=134) or obj. func. is infinite (error=136)

On Apr 22, 2016, at 9:14 PM, Leonid Gibiansky <lgibiansky_at_quantpharm.com<mailto:lgibiansky_at_quantpharm.com>> wrote: In $DES block I this expression DSIZE = LOG(BSL*(EXP(-DEC*TIME) + EXP(GRO*TIME) - 1)+1) I would use T rather than TIME You may also try tol nsig=4 sign Leonid On Apr 22, 2016, at 1:37 PM, Mai, Tu [MED] <tmai1_at_medicine.bsd.uchicago.edu<mailto:tmai1_at_medicine.bsd.uchicago.edu>> wrote: Dear NMUsers, Our model keeps having the rounding error (error4). I tried to fix it using the following methods or their combinations, however, sometimes I then got the message error6 instead of error4. But minimization still unsuccessful. Can you please help pointing out how I can solve this problem? I really appreciate it! Thank you 1) Use the estimates for THETA that are ~10% deviated from the estimates provided after scm run. 2) Set TOL=9, NSIG=2, SIGL=6 I attached here the code: $PROBLEM IRM code $INPUT ID TIME EX DV DVID ECOG AGE HT WT RACE SITE DIAG=DROP HEM ALK ALB LAC TES STUDY DRUG PRIORDOC $DATA survival.csv $SUBROUTINE ADVAN13 TOL=9 $MODEL NCOMP=1 COMP(HAZ) $PK ;;; DECECOG-DEFINITION START IF(ECOG.EQ.1) DECECOG = 1 ; Most common IF(ECOG.EQ.0) DECECOG = ( 1 + THETA(27)) IF(ECOG.EQ.2) DECECOG = ( 1 + THETA(28)) ;;; DECECOG-DEFINITION END ;;; GROPRIORDOC-DEFINITION START IF(PRIORDOC.EQ.0) GROPRIORDOC = 1 ; Most common IF(PRIORDOC.EQ.1) GROPRIORDOC = ( 1 + THETA(26)) ;;; GROPRIORDOC-DEFINITION END ;;; GROECOG-DEFINITION START IF(ECOG.EQ.1) GROECOG = 1 ; Most common IF(ECOG.EQ.0) GROECOG = ( 1 + THETA(24)) IF(ECOG.EQ.2) GROECOG = ( 1 + THETA(25)) ;;; GROECOG-DEFINITION END ;;; GROALK-DEFINITION START IF(ALK.EQ.-99) THEN GROALK = 1 ELSE GROALK = ( 1 + THETA(23)*(ALK - 94.00)) ENDIF ;;; GROALK-DEFINITION END ;;; GRO-RELATION START GROCOV=GROALK*GROECOG*GROPRIORDOC ;;; GRO-RELATION END ;;; DECDRUG-DEFINITION START IF(DRUG.EQ.3) DECDRUG = 1 ; Most common IF(DRUG.EQ.2) DECDRUG = ( 1 + THETA(21)) IF(DRUG.EQ.1) DECDRUG = ( 1 + THETA(22)) ;;; DECDRUG-DEFINITION END ;;; DECAGE-DEFINITION START DECAGE = ( 1 + THETA(20)*(AGE - 64.00)) ;;; DECAGE-DEFINITION END ;;; DEC-RELATION START DECCOVCAGE*DECDRUG*DECECOG ;;; DEC-RELATION END ;;; BSLHEM-DEFINITION START IF(HEM.LE.124.00) BSLHEM = ( 1 + THETA(18)*(HEM - 124.00)) IF(HEM.GT.124.00) BSLHEM = ( 1 + THETA(19)*(HEM - 124.00)) IF(HEM.EQ.-99) BSLHEM = 1 ;;; BSLHEM-DEFINITION END ;;; BSLECOG-DEFINITION START IF(ECOG.EQ.1) BSLECOG = 1 ; Most common IF(ECOG.EQ.0) BSLECOG = ( 1 + THETA(16)) IF(ECOG.EQ.2) BSLECOG = ( 1 + THETA(17)) ;;; BSLECOG-DEFINITION END ;;; BSLALK-DEFINITION START IF(ALK.EQ.-99) THEN BSLALK = 1 ELSE BSLALK = ( 1 + THETA(15)*(ALK - 94.00)) ENDIF ;;; BSLALK-DEFINITION END ;;; BSL-RELATION START BSLCOV=BSLALK*BSLECOG*BSLHEM ;;; BSL-RELATION END ;;; BSHZPRIORDOC-DEFINITION START IF(PRIORDOC.EQ.0) BSHZPRIORDOC = 1 ; Most common IF(PRIORDOC.EQ.1) BSHZPRIORDOC = ( 1 + THETA(14)) ;;; BSHZPRIORDOC-DEFINITION END ;;; BSHZALK-DEFINITION START IF(ALK.EQ.-99) THEN BSHZALK = 1 ELSE BSHZALK = ( 1 + THETA(13)*(ALK - 94.00)) ENDIF ;;; BSHZALK-DEFINITION END ;;; BSHZ-RELATION START BSHZCOV=BSHZALK*BSHZPRIORDOC ;;; BSHZ-RELATION END ;;; BETAHEM-DEFINITION START IF(HEM.EQ.-99) THEN BETAHEM = 1 ELSE BETAHEM = ( 1 + THETA(12)*(HEM - 124.00)) ENDIF ;;; BETAHEM-DEFINITION END ;;; BETAECOG-DEFINITION START IF(ECOG.EQ.1) BETAECOG = 1 ; Most common IF(ECOG.EQ.0) BETAECOG = ( 1 + THETA(10)) IF(ECOG.EQ.2) BETAECOG = ( 1 + THETA(11)) ;;; BETAECOG-DEFINITION END ;;; BETADRUG-DEFINITION START IF(DRUG.EQ.3) BETADRUG = 1 ; Most common IF(DRUG.EQ.2) BETADRUG = ( 1 + THETA(8)) IF(DRUG.EQ.1) BETADRUG = ( 1 + THETA(9)) ;;; BETADRUG-DEFINITION END ;;; BETAAGE-DEFINITION START BETAAGE = ( 1 + THETA(7)*(AGE - 64.00)) ;;; BETAAGE-DEFINITION END ;;; BETA-RELATION START BETACOVTAAGE*BETADRUG*BETAECOG*BETAHEM ;;; BETA-RELATION END IF (NEWIND.LE.1) THEN SRVZ=1 ; Survivor function at TIME=0 ENDIF ;-----------BASELINE PSA-------------- TVBSL = THETA(1) TVBSL = BSLCOV*TVBSL BSL = TVBSL*EXP(ETA(1)) ;-----------PSA PARAMETERS-------------- TVGRO = THETA(2) TVGRO = GROCOV*TVGRO TVDEC = THETA(3) TVDEC = DECCOV*TVDEC GRO = TVGRO*EXP(ETA(2)) DEC = TVDEC*EXP(ETA(3)) ;-----------SURVIVAl MODEL PARAMETERS-------------- TVBSHZ = THETA(5) ; Baseline Hazard TVBSHZ = BSHZCOV*TVBSHZ BSHZ = TVBSHZ TVBETA = THETA(6) ; Parameter relating dropout hazard to PSA estimate TVBETA = BETACOV*TVBETA BETA = TVBETA $DES DSIZE = LOG(BSL*(EXP(-DEC*TIME) + EXP(GRO*TIME) - 1)+1) TEMP = BETA*DSIZE DADT(1) = BSHZ*EXP(TEMP) $ERROR IF (DVID.EQ.1) THEN F_FLAG=0 ; If continuous type data SIZE = LOG(BSL*(EXP(-DEC*TIME) + EXP(GRO*TIME) - 1)+1) IPRED = SIZE ADD = THETA(4) SDSIZE = SQRT(ADD*ADD) Y = SIZE + SDSIZE*EPS(1) W = Y IRES = DV-IPRED IWRES = IRES/(W) ENDIF ;-----------HAZARD PREDICTION-------------- CMHZ = A(1) SRVT = EXP(-CMHZ) IF (DVID.EQ.2.AND.DV.EQ.0) THEN F_FLAG=1 Y = SRVT ENDIF IF (DVID.EQ.2.AND.DV.EQ.1) THEN F_FLAG=1 Y = SRVZ-SRVT ENDIF $THETA (50,85,150) ; POP_BSL (0,0.0004,0.1) ; POP_GRO (0,0.02,0.1) ; POP_DEC (0,0.3,0.35) ; ADD_SD (0,0.0009,0.0014) ; BSHZ (0.1,0.3,0.7) ; BETA $THETA (-0.038,-0.003,0.016) ; BETAAGE1 $THETA (-1,0.3,5) ; BETADRUG1 (-1,0.1,5) ; BETADRUG2 $THETA (-1,-0.2,5) ; BETAECOG1 (-1,0.3,5) ; BETAECOG2 $THETA (-0.023,-0.01,0.016) ; BETAHEM1 $THETA (0,0.001,0.010) ; BSHZALK1 $THETA (-1,-0.4,5) ; BSHZPRIORDOC1 $THETA (0,0.002,0.010) ; BSLALK1 $THETA (-1,-0.3,5) ; BSLECOG1 (-1,0.2,5) ; BSLECOG2 $THETA (-1000000,-0.05,0.016) ; BSLHEM1 (-0.023,-0.0002,100) ; BSLHEM2 $THETA (-0.038,-0.0009,0.016) ; DECAGE1 $THETA (-1,-0.6,5) ; DECDRUG1 (-1,-0.8,5) ; DECDRUG2 $THETA (0,98E-006,0.010) ; GROALK1 $THETA (-1,-0.02,5) ; GROECOG1 (-1,0.5,5) ; GROECOG2 $THETA (-1,5,7) ; GROPRIORDOC1 $THETA (-1,0.0004,5) ; DECECOG1 (-1,-0.2,5) ; DECECOG2 $OMEGA 2.5 ; PPV_BSL 2 ; PPV_GRO 1.5 ; PPV_DEC ;------------------------- $SIGMA 1. FIX ;------------------------- $ESTIMATION METHOD=COND INTER NUMERICAL LAPLACE SLOW MAX99 NSIG=2 SIGL=6 NOABORT PRINT=5 $COVARIANCE $TABLE ID TIME IPRED BSL GRO DEC STUDY DRUG WRES CWRES ETA1 ETA2 ETA3 ONEHEADER NOPRINT FILE=C:\Users\fulldata.tab $TABLE ID TIME PRED RES WRES ONEHEADER NOPRINT FILE=C:\Users\original.tab ******************************************************************************** This e-mail is intended only for the use of the individual or entity to which it is addressed and may contain information that is privileged and confidential. If the reader of this e-mail message is not the intended recipient, you are hereby notified that any dissemination, distribution or copying of this communication is prohibited. If you have received this e-mail in error, please notify the sender and destroy all copies of the transmittal. Thank you University of Chicago Medicine and Biological Sciences ******************************************************************************** ******************************************************************************** This e-mail is intended only for the use of the individual or entity to which it is addressed and may contain information that is privileged and confidential. If the reader of this e-mail message is not the intended recipient, you are hereby notified that any dissemination, distribution or copying of this communication is prohibited. If you have received this e-mail in error, please notify the sender and destroy all copies of the transmittal. Thank you University of Chicago Medicine and Biological Sciences ********************************************************************************