Sr Pharmacometrician position at Vertex

Senior Pharmacometrican position at Vertex Pharmaceuticals, Boston Modeling & Simulation (M&S) methodologies plays an increasingly important role in the development of new drugs within Vertex Pharmaceuticals and our goal is to fully implement Model based principles to inform drug development program with respect to translational modeling, clinical trial design, PoPPK and PKPD , dose selection etc, and improve critical decision making. We are now seeking a Senior Pharmacometrician to our Modeling & Simulations (M&S) group to help us achieve this vision. The successful candidate will provide Modeling&Simulation expertise in one or several projects in close collaboration with colleagues in Clinical Pharmacology, Biostatistics, Preclinical Research and other colleagues within the R&D organization. Key responsibilities * Support project teams with state-of-the-art modeling expertise covering all phases of Drug development (Translational stage- Ph III/IV) * Perform Population PK, PKPD-analyses, Clinical trial simulations and other model based analyses on a regular basis * Deliver high quality M&S presentations and reports * Contribute to the continuous development of our M&S Department capabilities (tools, methods etc) Required Qualifications * PhD in PKPD, Clinical pharmacology, or other quantitative discipline with an emphasis on M&S and Pharmacometric methodologies * 3-5 yrs post PhD hands-on experience in the application of M&S and Pharmacometric methodologies within the context of drug development. * Excellent hands-on skills in Non-linear Mixed effect modeling and other modeling methodologies using NonMem, PsN, R, Phoenix, and other similar tools * A solid understanding of fundamental pharmacokinetic, quantitative pharmacology (PKPD), and Biostatistical principles. * Excellent collaborative, verbal and written communication skills Desirable qualifications * Experience from Pharmacometric analyses in Pulmonary diseases, Oncology or Neurological disorders. * Experience from the application of System pharmacology in a drug development context If you are interested in applying to the position, please go this link https://sjobs.brassring.com/TGWebHost/home.aspx?partnerid=25119&siteid=5134 Click search openings, under keyword type in 7930BR This email message and any attachments are confidential and intended for use by the addressee(s) only. If you are not the intended recipient, please notify me immediately by replying to this message, and destroy all copies of this message and any attachments. Thank you.