Re: BLQ Data
Hi Brady,
Have a look at this recently published paper by Ron Keizer and colleagues;
will answer your question.
"Incorporation of concentration data below the limit of quantification in
population pharmacokinetic analyses". Keizer et al, Pharmacol Res Perspect,
2015.
Best Regards,
Quoted reply history
On Fri, Oct 2, 2015 at 4:22 PM, Moffett, Brady S. <[email protected]> wrote:
> I am working with TDM data and am wondering when to use the M3 method for
> dealing with BLQ data, or, when to just exclude data?
>
>
>
> For instance: If I have <1% BLQ data in a large dataset (~1000 patients),
> should I just exclude those patients/values? If I just have one patient
> with one value BLQ, is it worth using the M3 method for that one patient?
> Is there a breakpoint for which using these methods does/does not make a
> difference?
>
>
>
> Thanks in advance…
>
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--
Ahmed Abbas Suleiman, MSc
PhD Candidate at Bonn University
Institute of Pharmacology - Clinical Pharmacology Unit
Hospital of the University of Cologne
Gleueler Str. 24, 50931 Cologne,
Germany