RE: forest plots in Xpose?
Dear all,
As a late entrant to this discussion, indeed there are many ways to Rome.
The dotplot function in R (lattice) could provide a similar visual output,
though not as elegant as the Metrum approach.The metrumrg package is not
available on the CRAN repository any longer, but on R forge.
best wishes
Amit Taneja
Research fellow, Pharmacometrics
Dept of Pharmacokinetics, Toxicology and Targeting
University of Groningen
The Netherlands
Quoted reply history
> From: [email protected]
> To: [email protected]; [email protected]
> Subject: RE: [NMusers] forest plots in Xpose?
> Date: Fri, 18 Sep 2015 20:51:20 +0000
>
> Dear All,
>
> Thanks all for your replies. I will not reply to each. Just to say that of
> course I know that forest plots come from Meta Analysis, which by the way may
> be already familiar to clinicians.
>
> It has been advocated by FDA to report DDI see (Menon-Andersen D, Yu B,
> Madabushi R, Bhattaram V, Hao W, Uppoor RS, Mehta M, Lesko L, Temple R,
> Stockbridge N, Laughren T, Gobburu JV. Essential pharmacokinetic information
> for drug dosage decisions: a concise visual presentation in the drug label.
> Clin Pharmacol Ther. 2011 Sep;90(3):471-4. ) and is suggested in Guidance
> doc:
> http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm292362.pdf
> http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/AdvisoryCommitteeforPharmaceuticalScienceandClinicalPharmacology/UCM370535.pdf
>
> I think it is an excellent way to communicate the results of covariate
> analysis, rather than giving an allometric/ power equation and a value of a
> parameter that does not speak to clinicians. I agree with Ron that it should
> be clearly stated what is presented and there are several ways of building
> it. In this respect the one given in the slides of Marc Gastonguay (thanks
> Andreas) is particularly appealing.
>
> With best regards / Mit freundlichen Grüßen / Cordialement
>
> Pascal
>
> -----Original Message-----
> From: [email protected] [mailto:[email protected]] On
> Behalf Of Paul Matthias Diderichsen
> Sent: 17 September 2015 09:12
> To: [email protected]
> Subject: Re: [NMusers] forest plots in Xpose?
>
> Ron, Pascal & NMUsers
>
> On 9/17/2015 2:08, Ron Keizer wrote:
> > On a sidenote, I'm not a fan of the term "Forest plot" for these plots.
> > The "original" Forest plots show data across multiple studies (e.g. in
> > a meta-analysis), so calling it "Forest plot" could lead to confusion
> > with statisticians or clinicians.
>
> I agree with Ron that Forest plots primarily exist in the meta analysis world.
>
> Pascal, maybe you are looking for "tornado plots"?
> ( https://en.wikipedia.org/wiki/Tornado_diagram)
>
> Here's a pointer to building a tornado plot with ggplot():
>
> http://stackoverflow.com/questions/6916698/tornado-chart-diagram-with-ggplot2
>
> --
> Paul Matthias Diderichsen, PhD
> Quantitative Solutions B.V.
> +31 624 330 706
>
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