Re: Imputation of multiple categorical covariates with missing data
hi Yassine,
There are alternatives to the mixture approach that would probably work
better in your case and can be used in the context of an scm too, see e.g.:
AAPS J. 2013 Oct;15(4):1232-41. doi: 10.1208/s12248-013-9526-y.
Comparison of methods for handling missing covariate data.
Johansson ÅM, Karlsson MO.
( http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787222)
AAPS J. 2012 Sep;14(3):601-11. doi: 10.1208/s12248-012-9373-2. Epub 2012
May 31.
Performance of methods for handling missing categorical covariate data in
population pharmacokinetic analyses.
Keizer RJ, Zandvliet AS, Beijnen JH, Schellens JH, Huitema AD.
( http://www.ncbi.nlm.nih.gov/pubmed/22648902)
best regards,
Ron
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