Re: ETAPvalues

Dear Ahmad, The ETA P-value is one of the diagnostics available for modelers. What it means and how important it is depends on your modeling objective and data. Having said that, in this case it seems that you have fixed thetas and omegas but left parent concentrations in the dataset. The lower ETA P-value indicates that the parent posthoc ETA distribution has shifted away from zero. This most likely means that your metabolite submodel has 'pulled' the parent posthoc away. You might want to look at the parent posthoc graphs to further investigate how the model shifted. Generally speaking this could mean that the metabolite model has some mismatch that is compensated by the parent etas. You might be able to update the metabolite (or parent) model to avoid this. If needed, you could also use a slightly different approach where you completely fix the parent model by appending your original posthocs to your dataset and apply them as a fixed input to the metabolite model and adjust. Afterwards you can see whether the updated model has improved ETA P-values. Hope this helps! Best regards, Jeroen http://pd-value.com [email protected] @PD_value +31 6 23118438 -- More value out of your data!