AW: Time 'T' in $Error

Dear Bill, dear all Thanks so much for your answer. More concrete I would like to model blood pressure including a circadian rhythm. Therefore I would like to use a sine or cosine function with ‘T’ instead of ‘Time’. SinfS = ( 1 + Amplitude * sin ( (2*PI/Period) * (T-Phase) ) ) ; sine or cosine function SBP = (SBas + SinfS) * (1-EffS) ; SBP = systolic blood pressure, SBas = Baseline systolic blood pressure, (1-EffS = effect) I could also model this effect using a turnover model and avoid this problem, but I would like to evaluate this kind of PD model (if there is any meaningful way to code). I also had the idea to code this sine function as a function of time in a compartment and rename this compartment in $Error, but I am not sure if there is any way to do this. Thanks again and best regards. Katrin Von: Denney, William S. [mailto:[email protected]] Gesendet: 27 July 2015 17:34 An: Katrin Volz <[email protected]>; [email protected] Betreff: RE: [NMusers] Time 'T' in $Error Hi Katrin, $ERROR is executed once per data row. The time when $ERROR is run is the TIME value (the discrete times of the measurement). For this specific example, you can just use TIME. You will need to code your $DES block so that what you’re wanting to integrate as a function of time is in a compartment amount (e.g. A(1)). With your example, it’s hard to see how T is used in the $DES, but perhaps you could share the real example to give a bit more concrete advice on how to integrate the answer into your code. Thanks, Bill